PDB entry 6sze

View 6sze on RCSB PDB site
Description: RIP2 Kinase Catalytic Domain complex with 5-Amino-1-Phenylpyrazole-4-Carboxamide.
Class: transferase
Keywords: Fragment Based Drug Design (FBDD), Receptor interacting protein 2 kinase, RIPK2, RIP2K, RIP2, Structure based drug design (SBDD), TRANSFERASE
Deposited on 2019-10-02, released 2019-10-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 2.94 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: receptor-interacting serine/threonine-protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6szea_
  • Chain 'B':
    Compound: receptor-interacting serine/threonine-protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6szeb_
  • Heterogens: M2B, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6szeA (A:)
gmngeaicsalptipyhkladlrylsrgasgtvssarhadwrvqvavkhlhihtplldse
rkdvlreaeilhkarfsyilpilgicnepeflgivteympngslnellhrkteypdvawp
lrfrilheialgvnylhnmtppllhhdlktqnilldnefhvkiadfglskwrmmslsqsr
ssksapeggtiiymppenyepgqksrasikhdiysyavitwevlsrkqpfedvtnplqim
ysvsqghrpvineeslpydiphrarmisliesgwaqnpderpsflkclielepvlrtfee
itfleaviqlk

    Sequence, based on observed residues (ATOM records): (download) 
    >6szeA (A:)
aicsalptipyhkladlrylsrgasgtvssarhadwrvqvavkhllldserkdvlreaei
lhkarfsyilpilgicnepeflgivteympngslnellhrkteypdvawplrfrilheia
lgvnylhnmtppllhhdlktqnilldnefhvkiadfglstiiymppenyesikhdiysya
vitwevlsrkqpfedvtnplqimysvsqghrpvineeslpydiphrarmisliesgwaqn
pderpsflkclielepvlrtfeeitfleaviqlk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6szeB (B:)
gmngeaicsalptipyhkladlrylsrgasgtvssarhadwrvqvavkhlhihtplldse
rkdvlreaeilhkarfsyilpilgicnepeflgivteympngslnellhrkteypdvawp
lrfrilheialgvnylhnmtppllhhdlktqnilldnefhvkiadfglskwrmmslsqsr
ssksapeggtiiymppenyepgqksrasikhdiysyavitwevlsrkqpfedvtnplqim
ysvsqghrpvineeslpydiphrarmisliesgwaqnpderpsflkclielepvlrtfee
itfleaviqlk

    Sequence, based on observed residues (ATOM records): (download) 
    >6szeB (B:)
aicsalptipyhkladlrylsrgtvssarhadwrvqvavkhlldserkdvlreaeilhka
rfsyilpilgicnepeflgivteympngslnellhrkteypdvawplrfrilheialgvn
ylhnmtppllhhdlktqnilldnefhvkiadfglskweggtiiymppenyepsikhdiys
yavitwevlsrkqpfedvtnplqimysvsqghrpvineeslpydiphrarmisliesgwa
qnpderpsflkclielepvlrtfeeitfleaviqlk