PDB entry 6sw3

View 6sw3 on RCSB PDB site
Description: Crystal structure of CREBBP bromodomain L1109W mutant
Class: transferase
Keywords: CREBBP, Bromodomain, TRANSFERASE, Mutant, L1109W
Deposited on 2019-09-19, released 2019-10-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-16, with a file datestamp of 2019-10-11.
Experiment type: XRAY
Resolution: 1.2 Å
R-factor: N/A
AEROSPACI score: 0.65 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cDNA FLJ57039, highly similar to CREB-binding protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot B4E3L4 (Start-118)
      • engineered mutation (30)
    Domains in SCOPe 2.08: d6sw3a_
  • Chain 'B':
    Compound: cDNA FLJ57039, highly similar to CREB-binding protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot B4E3L4 (2-118)
      • expression tag (1)
      • engineered mutation (30)
    Domains in SCOPe 2.08: d6sw3b1, d6sw3b2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6sw3A (A:)
smrkkifkpeelrqalmptlealyrqdpeswpfrqpvdpqllgipdyfdivknpmdlsti
krkldtgqyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqslg

    Sequence, based on observed residues (ATOM records): (download) 
    >6sw3A (A:)
kifkpeelrqalmptlealyrqdpeswpfrqpvdpqllgipdyfdivknpmdlstikrkl
dtgqyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqslg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6sw3B (B:)
smrkkifkpeelrqalmptlealyrqdpeswpfrqpvdpqllgipdyfdivknpmdlsti
krkldtgqyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqslg

    Sequence, based on observed residues (ATOM records): (download) 
    >6sw3B (B:)
mrkkifkpeelrqalmptlealyrqdpeswpfrqpvdpqllgipdyfdivknpmdlstik
rkldtgqyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqslg