PDB entry 6sv2

View 6sv2 on RCSB PDB site
Description: Human prion protein (PrP) fragment 119-231 (G127V M129 variant) complexed to ICSM 18 (anti-Prp therapeutic antibody) Fab fragment
Class: protein binding
Keywords: Prion, PROTEIN BINDING
Deposited on 2019-09-17, released 2020-07-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-12, with a file datestamp of 2020-08-07.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: major prion protein
    Species: Homo sapiens [TaxId:9606]
    Gene: PRNP, ALTPRP, PRIP, PRP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04156
      • engineered mutation (8)
    Domains in SCOPe 2.08: d6sv2a_
  • Chain 'H':
    Compound: icsm 18-anti-prp therapeutic fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6SV2 (0-214)
    Domains in SCOPe 2.08: d6sv2h_
  • Chain 'L':
    Compound: icsm 18-anti-prp therapeutic fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6SV2 (0-End)
    Domains in SCOPe 2.08: d6sv2l1, d6sv2l2
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6sv2A (A:)
gavvgglgvymlgsamsrpiihfgsdyedryyrenmhrypnqvyyrpmdeysnqnnfvhd
cvnitikqhtvttttkgenftetdvkmmervveqmcitqyeresqayyqrgss

    Sequence, based on observed residues (ATOM records): (download) 
    >6sv2A (A:)
lgvymlgsamsrpiihfgsdyedryyrenmhrypnqvyyrpmdeysnqnnfvhdcvniti
kqhtvttttkgenftetdvkmmervveqmcitqyeresqay

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6sv2H (H:)
evqlqqsgpelvkpgssvkisckasrntftdynldwvkqshgktlewignvypnngvtgy
nqkfrgkatltvdkssstaymelhsltsedsavyycalyyydvsywgqgtlvtvssaktt
ppsvyplapgsaaqtnsvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytls
ssvtvpsstwpsqsvtcnvahpasstavdkkiapa

    Sequence, based on observed residues (ATOM records): (download) 
    >6sv2H (H:)
evqlqqsgpelvkpgssvkisckasrntftdynldwvkqshgktlewignvypnngvtgy
nqkfrgkatltvdkssstaymelhsltsedsavyycalyyydvsywgqgtlvtvssaktt
ppsvyplapsvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlsssvtvps
stwpsqsvtcnvahpasstavdkkiapa

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6sv2L (L:)
qivltqspaimsaspgekvtmtcsasssvsymhwyqqksgtspkrwiydtsklasgvpar
fsgsgsgtsysltissmeaedaatyfchqwrsnpytfgggtkleikradaaptvsifpps
seqltgggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathktstspivksfnrne

    Sequence, based on observed residues (ATOM records): (download) 
    >6sv2L (L:)
qivltqspaimsaspgekvtmtcsasssvsymhwyqqksgtspkrwiydtsklasgvpar
fsgsgsgtsysltissmeaedaatyfchqwrsnpytfgggtkleikradaaptvsifpps
seqltgggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathktstspivksfnr