PDB entry 6sq4

View 6sq4 on RCSB PDB site
Description: Crystal structure of mouse PRMT6 in complex with inhibitor U2
Class: transferase
Keywords: SAM binding domain, arginine methylation, TRANSFERASE
Deposited on 2019-09-03, released 2020-09-30
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-09-30, with a file datestamp of 2020-09-25.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein arginine N-methyltransferase 6
    Species: Mus musculus [TaxId:10090]
    Gene: PRMT6, HRMT1L6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6NZB1
      • engineered mutation (314)
    Domains in SCOPe 2.07: d6sq4a_
  • Chain 'B':
    Compound: Protein arginine N-methyltransferase 6
    Species: Mus musculus [TaxId:10090]
    Gene: PRMT6, HRMT1L6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6NZB1
      • engineered mutation (314)
    Domains in SCOPe 2.07: d6sq4b_
  • Heterogens: GJV, IOD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6sq4A (A:)
mslskkrklesgdsggagaggegaeeenggeqeaapprprrtkserdqlyyecysdvsvh
eemiadqvrteayrlgilknwaalrgktvldvgagtgilsifcaqagarrvyaveasaiw
qqarevvrlngledrvhvlpgpvetvelpervdaivsewmgygllhesmlssvlhartkw
lkegglllpasaelfvapisdqmlewrlgfwsqvkqhygvdmscmesfatrclmghseiv
vqdlsgedvlarpqrfaqlelaragleqeleagvggrfrcscygsaplhgfavwfqvtfp
ggdsekplvlstsplhpathwkqallylnepvpveqdtdisgeitllpspdnprrlrill
rykvgdheektkdfamedgsenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6sq4A (A:)
rtkserdqlyyecysdvsvheemiadqvrteayrlgilknwaalrgktvldvgagtgils
ifcaqagarrvyaveasaiwqqarevvrlngledrvhvlpgpvetvelpervdaivsewm
gygllhesmlssvlhartkwlkegglllpasaelfvapisdqmlewrlgfwsqvkqhygv
dmscmesfatrclmghseivvqdlsgedvlarpqrfaqlelaragleqeleagvggrfrc
scygsaplhgfavwfqvtfpggdsekplvlstsplhpathwkqallylnepvpveqdtdi
sgeitllpspdnprrlrillrykvgdheektkdfam

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6sq4B (B:)
mslskkrklesgdsggagaggegaeeenggeqeaapprprrtkserdqlyyecysdvsvh
eemiadqvrteayrlgilknwaalrgktvldvgagtgilsifcaqagarrvyaveasaiw
qqarevvrlngledrvhvlpgpvetvelpervdaivsewmgygllhesmlssvlhartkw
lkegglllpasaelfvapisdqmlewrlgfwsqvkqhygvdmscmesfatrclmghseiv
vqdlsgedvlarpqrfaqlelaragleqeleagvggrfrcscygsaplhgfavwfqvtfp
ggdsekplvlstsplhpathwkqallylnepvpveqdtdisgeitllpspdnprrlrill
rykvgdheektkdfamedgsenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6sq4B (B:)
dqlyyecysdvsvheemiadqvrteayrlgilknwaalrgktvldvgagtgilsifcaqa
garrvyaveasaiwqqarevvrlngledrvhvlpgpvetvelpervdaivsewmgygllh
esmlssvlhartkwlkegglllpasaelfvapisdqmlewrlgfwsqvkqhygvdmscme
sfatrclmghseivvqdlsgedvlarpqrfaqlelaragleqeleagvggrfrcscygsa
plhgfavwfqvtfpkplvlstsplhpathwkqallylnepvpveqdtdisgeitllpspd
nprrlrillrykvgdheektkdfam