PDB entry 6sp4

View 6sp4 on RCSB PDB site
Description: keap1 in complex with compound 23
Class: protein binding
Keywords: NRF2, KEAP1, protein-protein interactions, Huntingtons disease, tetrahydroisoquinoline, PROTEIN BINDING
Deposited on 2019-08-30, released 2020-06-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-06-03, with a file datestamp of 2020-05-29.
Experiment type: XRAY
Resolution: 2.59 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kelch-like ECH-associated protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KEAP1, INRF2, KIAA0132, KLHL19
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14145 (Start-292)
      • conflict (223)
      • conflict (225)
    Domains in SCOPe 2.07: d6sp4a_
  • Chain 'B':
    Compound: Kelch-like ECH-associated protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KEAP1, INRF2, KIAA0132, KLHL19
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14145 (Start-292)
      • conflict (223)
      • conflict (225)
    Domains in SCOPe 2.07: d6sp4b_
  • Chain 'C':
    Compound: Kelch-like ECH-associated protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KEAP1, INRF2, KIAA0132, KLHL19
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14145 (Start-292)
      • conflict (223)
      • conflict (225)
    Domains in SCOPe 2.07: d6sp4c_
  • Chain 'D':
    Compound: Kelch-like ECH-associated protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KEAP1, INRF2, KIAA0132, KLHL19
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14145 (Start-292)
      • conflict (223)
      • conflict (225)
    Domains in SCOPe 2.07: d6sp4d_
  • Chain 'E':
    Compound: Kelch-like ECH-associated protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KEAP1, INRF2, KIAA0132, KLHL19
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14145 (Start-292)
      • conflict (223)
      • conflict (225)
    Domains in SCOPe 2.07: d6sp4e_
  • Chain 'F':
    Compound: Kelch-like ECH-associated protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KEAP1, INRF2, KIAA0132, KLHL19
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14145 (Start-292)
      • conflict (223)
      • conflict (225)
    Domains in SCOPe 2.07: d6sp4f_
  • Heterogens: LQK, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6sp4A (A:)
gshmapkvgrliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllya
vggrnnspdgntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcih
hnsveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyyperne
wrmitamntirsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsa
lgitvhqgriyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

    Sequence, based on observed residues (ATOM records): (download) 
    >6sp4A (A:)
rliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllyavggrnnspd
gntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcihhnsveryep
erdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitamnt
irsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsalgitvhqgr
iyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6sp4B (B:)
gshmapkvgrliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllya
vggrnnspdgntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcih
hnsveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyyperne
wrmitamntirsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsa
lgitvhqgriyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

    Sequence, based on observed residues (ATOM records): (download) 
    >6sp4B (B:)
grliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllyavggrnnsp
dgntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcihhnsverye
perdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitamn
tirsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsalgitvhqg
riyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6sp4C (C:)
gshmapkvgrliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllya
vggrnnspdgntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcih
hnsveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyyperne
wrmitamntirsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsa
lgitvhqgriyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

    Sequence, based on observed residues (ATOM records): (download) 
    >6sp4C (C:)
rliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllyavggrnnspd
gntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcihhnsveryep
erdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitamnt
irsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsalgitvhqgr
iyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6sp4D (D:)
gshmapkvgrliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllya
vggrnnspdgntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcih
hnsveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyyperne
wrmitamntirsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsa
lgitvhqgriyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

    Sequence, based on observed residues (ATOM records): (download) 
    >6sp4D (D:)
rliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllyavggrnnspd
gntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcihhnsveryep
erdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitamnt
irsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsalgitvhqgr
iyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6sp4E (E:)
gshmapkvgrliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllya
vggrnnspdgntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcih
hnsveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyyperne
wrmitamntirsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsa
lgitvhqgriyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

    Sequence, based on observed residues (ATOM records): (download) 
    >6sp4E (E:)
rliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllyavggrnnspd
gntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcihhnsveryep
erdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitamnt
irsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsalgitvhqgr
iyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6sp4F (F:)
gshmapkvgrliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllya
vggrnnspdgntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcih
hnsveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyyperne
wrmitamntirsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsa
lgitvhqgriyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

    Sequence, based on observed residues (ATOM records): (download) 
    >6sp4F (F:)
vgrliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllyavggrnns
pdgntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcihhnsvery
eperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitam
ntirsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsalgitvhq
griyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt