PDB entry 6sp1

View 6sp1 on RCSB PDB site
Description: keap1 in complex with compound 6
Class: protein binding
Keywords: NRF2, KEAP1, protein-protein interactions, Huntingtons disease, tetrahydroisoquinoline, PROTEIN BINDING
Deposited on 2019-08-30, released 2020-06-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-06-03, with a file datestamp of 2020-05-29.
Experiment type: XRAY
Resolution: 2.57 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kelch-like ECH-associated protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KEAP1, INRF2, KIAA0132, KLHL19
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14145 (Start-292)
      • conflict (223)
      • conflict (225)
    Domains in SCOPe 2.07: d6sp1a_
  • Chain 'B':
    Compound: Kelch-like ECH-associated protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KEAP1, INRF2, KIAA0132, KLHL19
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14145 (Start-292)
      • conflict (223)
      • conflict (225)
    Domains in SCOPe 2.07: d6sp1b_
  • Heterogens: LQ8, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6sp1A (A:)
gshmapkvgrliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllya
vggrnnspdgntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcih
hnsveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyyperne
wrmitamntirsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsa
lgitvhqgriyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

    Sequence, based on observed residues (ATOM records): (download) 
    >6sp1A (A:)
grliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllyavggrnnsp
dgntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcihhnsverye
perdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitamn
tirsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsalgitvhqg
riyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6sp1B (B:)
gshmapkvgrliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllya
vggrnnspdgntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcih
hnsveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyyperne
wrmitamntirsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsa
lgitvhqgriyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt

    Sequence, based on observed residues (ATOM records): (download) 
    >6sp1B (B:)
grliytaggyfrqslsyleaynpsdgtwlrladlqvprsglagcvvggllyavggrnnsp
dgntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcihhnsverye
perdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitamn
tirsgagvcvlhnciyaaggydgqdqlnsverydvatatwtfvapmkhrrsalgitvhqg
riyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavt