PDB entry 6slg

View 6slg on RCSB PDB site
Description: human erk2 with erk1/2 inhibitor, azd0364.
Class: transferase
Keywords: erk2, kinase, inhibitor, oncology, transferase
Deposited on 2019-08-19, released 2019-11-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: XRAY
Resolution: 1.33 Å
R-factor: N/A
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28482
      • conflict (64)
    Domains in SCOPe 2.08: d6slga_
  • Chain 'B':
    Compound: ERK-tide
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed):
    • PDB 6SLG (0-4)
  • Heterogens: LHZ, SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6slgA (A:)
mhhhhhhgggenlyfqgshmaaaaaagagpemvrgqvfdvgprytnlsyigegaygmvcs
aydnlnkvrvaikkispfehqtycqrtlreikillrfrheniigindiiraptieqmkdv
yivqdlmetdlykllktqhlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttc
dlkicdfglarvadpdhdhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaem
lsnrpifpgkhyldqlnhilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpn
adskaldlldkmltfnphkrieveqalahpyleqyydpsdepiaeapfkfdmelddlpke
klkelifeetarfqpgyrsle

    Sequence, based on observed residues (ATOM records): (download) 
    >6slgA (A:)
vfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrtlreikillr
frheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqilrgl
kyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatrwyrape
imlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciin
lkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyy
dpsdepiaeapfklpkeklkelifeetarfqp

  • Chain 'B':
    No sequence available.