PDB entry 6skd

View 6skd on RCSB PDB site
Description: Crystal Structure of Human Kallikrein 6 (I218Y) in complex with GSK3397892A
Class: hydrolase
Keywords: Protease, Inhibitor, Complex, HYDROLASE
Deposited on 2019-08-15, released 2019-09-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-02, with a file datestamp of 2019-09-27.
Experiment type: XRAY
Resolution: 2.26 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kallikrein-6
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK6, PRSS18, PRSS9
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92876 (0-End)
      • engineered mutation (56)
      • engineered mutation (58)
      • engineered mutation (112)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6skda_
  • Chain 'B':
    Compound: Kallikrein-6
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK6, PRSS18, PRSS9
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92876 (0-End)
      • engineered mutation (56)
      • engineered mutation (58)
      • engineered mutation (112)
      • engineered mutation (194)
    Domains in SCOPe 2.08: d6skdb_
  • Heterogens: LH2, UNX, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6skdA (A:)
lvhggpcdktshpyqaalytsghllcggvlihplwvltaahckkpnlqvflgkhnlgqqe
ssqeqssvvravihpdydaashdqdimllrlarpaklseliqplplerdcsaqttschil
gwgktadgdfpdtiqcayihlvsreecehaypgqitqnmlcagdekygkdscqgdsggpl
vcgdhlrglvswgnypcgskekpgvytnvcrytnwiqktiqak

    Sequence, based on observed residues (ATOM records): (download) 
    >6skdA (A:)
lvhggpcdktshpyqaalytsghllcggvlihplwvltaahckkpnlqvflgkhnlgqqe
ssqeqssvvravihpdydaashdqdimllrlarpaklseliqplplerdcsaqttschil
gwgktadgdfpdtiqcayihlvsreecehaypgqitqnmlcagdekygkdscqgdsggpl
vcgdhlrglvswgnypcgskekpgvytnvcrytnwiqktiqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6skdB (B:)
lvhggpcdktshpyqaalytsghllcggvlihplwvltaahckkpnlqvflgkhnlgqqe
ssqeqssvvravihpdydaashdqdimllrlarpaklseliqplplerdcsaqttschil
gwgktadgdfpdtiqcayihlvsreecehaypgqitqnmlcagdekygkdscqgdsggpl
vcgdhlrglvswgnypcgskekpgvytnvcrytnwiqktiqak

    Sequence, based on observed residues (ATOM records): (download) 
    >6skdB (B:)
lvhggpcdktshpyqaalytsghllcggvlihplwvltaahckkpnlqvflgkhnlgqqe
ssqeqssvvravihpdydaashdqdimllrlarpaklseliqplplerdcsaqttschil
gwgktadgdfpdtiqcayihlvsreecehaypgqitqnmlcagdekygkdscqgdsggpl
vcgdhlrglvswgnypcgskekpgvytnvcrytnwiqktiqa