PDB entry 6sj7

View 6sj7 on RCSB PDB site
Description: structure of the human ddb1-dda1-dcaf15 e3 ubiquitin ligase bound to rbm39 and indisulam
Deposited on 2019-08-12, released 2019-12-18
The last revision was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: EM
Resolution: 3.54 Å
R-factor: N/A
AEROSPACI score: 0.07 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DDB1- and CUL4-associated factor 15
    Species: Homo sapiens [TaxId:9606]
    Gene: DCAF15, C19orf72
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: DNA damage-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: DDB1, XAP1
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: RNA binding protein 39
    Species: Homo sapiens [TaxId:9606]
    Gene: DKFZp781I1140
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: DET1- and DDB1-associated protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: DDA1, C19orf58, PCIA1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: EF6

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6sj7A (A:)
gpapssksernsgagsggggpggaggkraagrrrehvlkqlervkisgqlsprlfrklpp
rvcvslknivdedflyaghiflgfskcgryvlsytsssgdddfsfyiyhlywwefnvhsk
lklvrqvrlfqdeeiysdlyltvcewpsdaskvivfgfntrsangmlmnmmmmsdenhrd
iyvstvavpppgrcaacqdasrahpgdpnaqclrhgfmlhtkyqvvypfptfqpafqlkk
dqvvllntsyslvacavsvhsagdrsfcqilydhstcplapasppepqspelppalpsfc
peaaparssgspepspaiakakefvadifrrakeakggvpeearpalcpgpsgsrcrahs
eplalcgetaprdsppaseapasepgyvnytklyyvlesgegtepedeleddkislpfvv
tdlrgrnlrpmrertavqgqyltveqltldfeyvinevirhdatwghqfcsfsdydivil
evcpetnqvlinigllllafpspteegqlrpktyhtslkvawdlntgifetvsvgdltev
kgqtsgsvwssyrkscvdmvmkwlvpessgryvnrmtnealhkgcslkvladserytwiv
l

    Sequence, based on observed residues (ATOM records):
    >6sj7A (A:)
ehvlkqlervkisgqlsprlfrklpprvcvslknivdedaghiflgfskcgryvlsytss
fyiyhlywwefnvhsklklvrqvrlfqdeeiysdlyltvcewpsdaskvivfgfntrsan
msdenhrdiyvstvavpppgrcdpnaqclrhgfmlhtkyqvvpfptfqpafqlkkdqvvl
lntsyslvacavsvhsfcqilvvtdlrgrnlrpmrqyltveqltldfeyvinevirhdat
wghqfcsfsdydivilevcpetnqvlinigllllapktyhtslkvawdlntfetvsvgdl
tevkqtsgsvwssyrkscvdmvmkwlvpessgryvnrmtneavladserytwivl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6sj7B (B:)
msynyvvtaqkptavngcvtghftsaedlnlliakntrleiyvvtaeglrpvkevgmygk
iavmelfrpkgeskdllfiltakynacileykqsgesidiitrahgnvqdrigrpsetgi
igiidpecrmiglrlydglfkvipldrdnkelkafnirleelhvidvkflygcqapticf
vyqdpqgrhvktyevslrekefnkgpwkqenveaeasmviavpepfggaiiigqesityh
ngdkylaiappiikqstivchnrvdpngsryllgdmegrlfmlllekeeqmdgtvtlkdl
rvellgetsiaecltyldngvvfvgsrlgdsqlvklnvdsneqgsyvvametftnlgpiv
dmcvvdlerqgqgqlvtcsgafkegslriirngigihehasidlpgikglwplrsdpnre
tddtlvlsfvgqtrvlmlngeeveetelmgfvddqqtffcgnvahqqliqitsasvrlvs
qepkalvsewkepqaknisvascnssqvvvavgralyylqihpqelrqishtemehevac
lditplgdsnglsplcaiglwtdisarilklpsfellhkemlggeiiprsilmttfessh
yllcalgdgalfyfglnietgllsdrkkvtlgtqptvlrtfrslsttnvfacsdrptviy
ssnhklvfsnvnlkevnymcplnsdgypdslalannstltigtideiqklhirtvplyes
prkicyqevsqcfgvlssrievqdtsggttalrpsastqalsssvsssklfssstaphet
sfgeevevhnlliidqhtfevlhahqflqneyalslvscklgkdpntyfivgtamvypee
aepkqgrivvfqysdgklqtvaekevkgavysmvefngkllasinstvrlyewttekelr
tecnhynnimalylktkgdfilvgdlmrsvlllaykpmegnfeeiardfnpnwmsaveil
dddnflgaenafnlfvcqkdsaattdeerqhlqevglfhlgefvnvfchgslvmqnlget
stptqgsvlfgtvngmiglvtslseswynllldmqnrlnkviksvgkiehsfwrsfhter
ktepatgfidgdliesfldisrpkmqevvanlqyddgsgmkreataddlikvveeltrih

    Sequence, based on observed residues (ATOM records):
    >6sj7B (B:)
msynyvvtaqkptavngcvtghftsaedlnlliakntrleiyvvtaeglrpvkevgmygk
iavmelfrpkgeskdllfiltakynacileykqsgesidiitrahgnvqdrigrpsetgi
igiidpecrmiglrlydglfkvipldrdnkelkafnirleelhvidvkflygcqapticf
vyqrhvktyevslrekefnkgpwkqenveaeasmviavpepfggaiiigqesityhngdk
ylaiappiikqstivchnrvdpngsryllgdmegrlfmlllekeeqmgtvtlkdlrvell
getsiaecltyldngvvfvgsrlgdsqlvklnvdsneqgsyvvametftnlgpivdmcvv
dlerqgqgqlvtcsgafkegslriirngklhirtvplyesprkicyqevsqcfgvlssri
evqdtsggttalrpsastqalsssvsssklfgeevevhnlliidqhtfevlhahqflqne
yalslvscklgkdpntyfivgtamvypeeaepkqgrivvfqysdgklqtvaekevkgavy
smvefngkllasinstvrlyewttekelrtecnhymalylktkgdfilvgdlmrsvllla
yfeeiardfnpnwmsaveildddnflgaenafnlfvcqkdstdeerqhlqevglfhlgef
vnvfchgslvgsvlfgtvngmiglvtslseswynllldmqnrlnkviksvgkiehsfwrs
fhterktepatgfidgdliesfldisrpkmqevvanlataddlikvveeltrih

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6sj7C (C:)
gpmrlyvgslhfnitedmlrgifepfgriesiqlmmdsetgrskgygfitfsdsecakka
leqlngfelagrpmkvghvte

    Sequence, based on observed residues (ATOM records):
    >6sj7C (C:)
mrlyvgslhfnitedmlrgifepfgriesiqlmmdsetgrskgygfitfsdsecakkale
qlngfelagrpmkvghvte

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6sj7D (D:)
adflkglpvynksnfsrfhadsvckasnrrpsvylptreypseqiivtektnillrylhq
qwdkknaakkrdqeqvelegessapprkvartdspdmhedt

    Sequence, based on observed residues (ATOM records):
    >6sj7D (D:)
lkglpvynksnfsrfrpsvylptreypseqiivtektnillrylhqqwdkkn