PDB entry 6shh

View 6shh on RCSB PDB site
Description: Human kallikrein 7 with aromatic coumarinic ester compound 1 covalently bound to H57
Class: hydrolase
Keywords: Serine Protease, Covalent Inhibitor, Complex, HYDROLASE
Deposited on 2019-08-06, released 2020-05-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-06-24, with a file datestamp of 2020-06-19.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kallikrein-7
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK7, PRSS6, SCCE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6shha_
  • Chain 'B':
    Compound: Kallikrein-7
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK7, PRSS6, SCCE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6shhb_
  • Chain 'C':
    Compound: Kallikrein-7
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK7, PRSS6, SCCE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6shhc_
  • Chain 'D':
    Compound: Kallikrein-7
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK7, PRSS6, SCCE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6shhd_
  • Chain 'E':
    Compound: Kallikrein-7
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK7, PRSS6, SCCE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6shhe_
  • Chain 'F':
    Compound: Kallikrein-7
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK7, PRSS6, SCCE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6shhf_
  • Chain 'G':
    Compound: Kallikrein-7
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK7, PRSS6, SCCE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6shhg_
  • Chain 'H':
    Compound: Kallikrein-7
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK7, PRSS6, SCCE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6shhh_
  • Heterogens: PGE, SO4, SH7, EPE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6shhA (A:)
iidgapcargshpwqvallsgnqlhcggvlvnerwvltaahckmneytvhlgsdtlgdrr
aqrikasksfrhpgystqthvndlmlvklnsqarlssmvkkvrlpsrceppgttctvsgw
gtttspdvtfpsdlmcvdvklispqdctkvykdllensmlcagipdskknacngdsggpl
vcrgtlqglvswgtfpcgqpndpgvytqvckftkwindtmkkhr

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6shhB (B:)
iidgapcargshpwqvallsgnqlhcggvlvnerwvltaahckmneytvhlgsdtlgdrr
aqrikasksfrhpgystqthvndlmlvklnsqarlssmvkkvrlpsrceppgttctvsgw
gtttspdvtfpsdlmcvdvklispqdctkvykdllensmlcagipdskknacngdsggpl
vcrgtlqglvswgtfpcgqpndpgvytqvckftkwindtmkkhr

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6shhC (C:)
iidgapcargshpwqvallsgnqlhcggvlvnerwvltaahckmneytvhlgsdtlgdrr
aqrikasksfrhpgystqthvndlmlvklnsqarlssmvkkvrlpsrceppgttctvsgw
gtttspdvtfpsdlmcvdvklispqdctkvykdllensmlcagipdskknacngdsggpl
vcrgtlqglvswgtfpcgqpndpgvytqvckftkwindtmkkhr

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6shhD (D:)
iidgapcargshpwqvallsgnqlhcggvlvnerwvltaahckmneytvhlgsdtlgdrr
aqrikasksfrhpgystqthvndlmlvklnsqarlssmvkkvrlpsrceppgttctvsgw
gtttspdvtfpsdlmcvdvklispqdctkvykdllensmlcagipdskknacngdsggpl
vcrgtlqglvswgtfpcgqpndpgvytqvckftkwindtmkkhr

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6shhE (E:)
iidgapcargshpwqvallsgnqlhcggvlvnerwvltaahckmneytvhlgsdtlgdrr
aqrikasksfrhpgystqthvndlmlvklnsqarlssmvkkvrlpsrceppgttctvsgw
gtttspdvtfpsdlmcvdvklispqdctkvykdllensmlcagipdskknacngdsggpl
vcrgtlqglvswgtfpcgqpndpgvytqvckftkwindtmkkhr

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6shhF (F:)
iidgapcargshpwqvallsgnqlhcggvlvnerwvltaahckmneytvhlgsdtlgdrr
aqrikasksfrhpgystqthvndlmlvklnsqarlssmvkkvrlpsrceppgttctvsgw
gtttspdvtfpsdlmcvdvklispqdctkvykdllensmlcagipdskknacngdsggpl
vcrgtlqglvswgtfpcgqpndpgvytqvckftkwindtmkkhr

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6shhG (G:)
iidgapcargshpwqvallsgnqlhcggvlvnerwvltaahckmneytvhlgsdtlgdrr
aqrikasksfrhpgystqthvndlmlvklnsqarlssmvkkvrlpsrceppgttctvsgw
gtttspdvtfpsdlmcvdvklispqdctkvykdllensmlcagipdskknacngdsggpl
vcrgtlqglvswgtfpcgqpndpgvytqvckftkwindtmkkhr

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6shhH (H:)
iidgapcargshpwqvallsgnqlhcggvlvnerwvltaahckmneytvhlgsdtlgdrr
aqrikasksfrhpgystqthvndlmlvklnsqarlssmvkkvrlpsrceppgttctvsgw
gtttspdvtfpsdlmcvdvklispqdctkvykdllensmlcagipdskknacngdsggpl
vcrgtlqglvswgtfpcgqpndpgvytqvckftkwindtmkkhr