PDB entry 6sge

View 6sge on RCSB PDB site
Description: Crystal structure of Human RHOB-GTP in complex with nanobody B6
Class: immune system
Keywords: GTPase, RHO, antibody, complex, immune system
Deposited on 2019-08-04, released 2019-09-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Rho-related GTP-binding protein RhoB
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOB, ARH6, ARHB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62745
      • engineered mutation (62)
    Domains in SCOPe 2.08: d6sgea_
  • Chain 'B':
    Compound: Nanobody B6
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A4E0W6L3 (1-End)
      • expression tag (0)
      • conflict (4-5)
      • conflict (10)
      • conflict (26-30)
      • conflict (32)
      • conflict (34)
      • conflict (36)
      • conflict (43-44)
      • conflict (46)
      • insertion (48)
      • conflict (49)
      • conflict (51-56)
      • conflict (58)
      • conflict (79)
      • conflict (93)
      • conflict (98-104)
      • conflict (106)
      • conflict (108)
      • insertion (110-111)
      • conflict (113)
      • conflict (119)
    Domains in SCOPe 2.08: d6sgeb1, d6sgeb2
  • Chain 'C':
    Compound: Rho-related GTP-binding protein RhoB
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOB, ARH6, ARHB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62745 (Start-182)
      • engineered mutation (62)
    Domains in SCOPe 2.08: d6sgec_
  • Chain 'D':
    Compound: Nanobody B6
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A4E0W6L3 (1-127)
      • expression tag (0)
      • conflict (4-5)
      • conflict (10)
      • conflict (26-30)
      • conflict (32)
      • conflict (34)
      • conflict (36)
      • conflict (43-44)
      • conflict (46)
      • insertion (48)
      • conflict (49)
      • conflict (51-56)
      • conflict (58)
      • conflict (79)
      • conflict (93)
      • conflict (98-104)
      • conflict (106)
      • conflict (108)
      • insertion (110-111)
      • conflict (113)
      • conflict (119)
      • expression tag (128-133)
    Domains in SCOPe 2.08: d6sged1, d6sged2, d6sged3
  • Heterogens: GTP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6sgeA (A:)
maairkklvvvgdgacgktcllivfskdefpevyvptvfenyvadievdgkqvelalwdt
agledydrlrplsypdtdvilmcfsvdspdslenipekwvpevkhfcpnvpiilvankkd
lrsdehvrtelarmkqepvrtddgramavriqaydylecsaktkegvrevfetatraalq
kry

    Sequence, based on observed residues (ATOM records): (download) 
    >6sgeA (A:)
airkklvvvgdgacgktcllivfskdefpevyvptvfenyvadievdgkqvelalwdtag
ledydrlrplsypdtdvilmcfsvdspdslenipekwvpevkhfcpnvpiilvankkdlr
sdehvrtelarmkqepvrtddgramavriqaydylecsaktkegvrevfetatraalq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6sgeB (B:)
avqlqasgggfvqpggslrlscaasgygstietmgwfrqapgkerefvsaisrapgpsqy
yadsvkgrftisrdnskntvylqmnslraedtatyycapinnrtmqdsmflwnywgqgtq
vtvssaaaenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6sgeB (B:)
avqlqasgggfvqpggslrlscaasgygstietmgwfrqapgkerefvsaisrapgpsqy
yadsvkgrftisrdnskntvylqmnslraedtatyycapinnrtmqdsmflwnywgqgtq
vtvssa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6sgeC (C:)
maairkklvvvgdgacgktcllivfskdefpevyvptvfenyvadievdgkqvelalwdt
agledydrlrplsypdtdvilmcfsvdspdslenipekwvpevkhfcpnvpiilvankkd
lrsdehvrtelarmkqepvrtddgramavriqaydylecsaktkegvrevfetatraalq
kry

    Sequence, based on observed residues (ATOM records): (download) 
    >6sgeC (C:)
aairkklvvvgdgacgktcllivfskdefpevyvptvfenyvadievdgkqvelalwdta
gledydrlrplsypdtdvilmcfsvdspdslenipekwvpevkhfcpnvpiilvankkdl
rsdehvrtelarmkqepvrtddgramavriqaydylecsaktkegvrevfetatraalqk
ry

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6sgeD (D:)
avqlqasgggfvqpggslrlscaasgygstietmgwfrqapgkerefvsaisrapgpsqy
yadsvkgrftisrdnskntvylqmnslraedtatyycapinnrtmqdsmflwnywgqgtq
vtvssaaaenlyfq