PDB entry 6sfr

View 6sfr on RCSB PDB site
Description: SOS1 in Complex with Inhibitor BI-68BS
Class: oncoprotein
Keywords: Oncology, exchange factor, protein-ligand complex, ONCOPROTEIN
Deposited on 2019-08-02, released 2020-08-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-02, with a file datestamp of 2021-05-28.
Experiment type: XRAY
Resolution: 1.92 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07889 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d6sfra1, d6sfra2
  • Chain 'B':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6sfrb_
  • Heterogens: LBK, IMD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6sfrA (A:)
geeqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpn
fvrtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyi
qpvqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkki
ardngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqps
elvgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvf
qelnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsi
nppcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclr
vesdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrp
snprpgt

    Sequence, based on observed residues (ATOM records): (download) 
    >6sfrA (A:)
geeqmrlpsadvyrfaepdseeniifegipiikagtviklierltyhmyadpnfvrtflt
tyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlrv
lnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiardtfqs
spptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkei
nspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvs
amnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltn
ilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnp
mgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6sfrB (B:)
geeqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpn
fvrtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyi
qpvqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkki
ardngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqps
elvgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvf
qelnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsi
nppcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclr
vesdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrp
snprpgt

    Sequence, based on observed residues (ATOM records): (download) 
    >6sfrB (B:)
eqmrlpsadvyrfaepdseeniifegipiikagtviklierltyhmyadpnfvrtfltty
rsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlrvln
vcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiarfqssppt
vewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkeinspn
llkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsamns
spvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltnilkt
eegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpmgns
mekeftdylfnksleieprnpkplprfpkkysyplkspgvrp