PDB entry 6sfi

View 6sfi on RCSB PDB site
Description: Crystal structure of p38 alpha in complex with compound 75 (MCP33)
Class: transferase
Keywords: p38a, MAPK, MAPK14, kinase inhibitor, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Deposited on 2019-08-01, released 2019-09-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-29, with a file datestamp of 2020-01-24.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 14
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16539
      • conflict (48)
      • conflict (263)
    Domains in SCOPe 2.08: d6sfia_
  • Heterogens: LB5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6sfiA (A:)
gmsqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpf
qsiihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkc
qkltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddem
tgyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlv
gtpgaellkkissesarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkrita
aqalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppldqeeme
s

    Sequence, based on observed residues (ATOM records): (download) 
    >6sfiA (A:)
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglaratrwyrapei
mlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkisse
sarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhd
pddepvadpydqsfesrdllidewksltydevisfvpppl