PDB entry 6sdt

View 6sdt on RCSB PDB site
Description: human carbonic anhydrase vii in complex with a sulfonamide inhibitor
Class: lyase
Keywords: carbonic anhydrase vii, zinc enzyme, inhibitor, sulfonamide, lyase
Deposited on 2019-07-29, released 2020-06-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-06-10, with a file datestamp of 2020-06-05.
Experiment type: XRAY
Resolution: 1.94 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: CA7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43166 (Start-265)
      • engineered mutation (186)
      • engineered mutation (220)
    Domains in SCOPe 2.08: d6sdta_
  • Heterogens: L8N, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6sdtA (A:)
    mgmtghhgwgygqddgpshwhklypiaqgdrqspiniissqavyspslqplelsyeacms
    lsitnnghsvqvdfndsddrtvvtggplegpyrlkqfhfhwgkkhdvgsehtvdgksfps
    elhlvhwnakkystfgeaasapdglavvgvfletgdehpsmnrltdalymvrfkgtkaqf
    scfnpksllpasrhywtypgslttpplsesvtwivlrepisiserqmgkfrsllftsedd
    erihmvnnfrppqplkgrvvkasfralehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >6sdtA (A:)
    gwgygqddgpshwhklypiaqgdrqspiniissqavyspslqplelsyeacmslsitnng
    hsvqvdfndsddrtvvtggplegpyrlkqfhfhwgkkhdvgsehtvdgksfpselhlvhw
    nakkystfgeaasapdglavvgvfletgdehpsmnrltdalymvrfkgtkaqfscfnpks
    llpasrhywtypgslttpplsesvtwivlrepisiserqmgkfrsllftsedderihmvn
    nfrppqplkgrvvkasfra