PDB entry 6scm

View 6scm on RCSB PDB site
Description: SOS1 in Complex with Inhibitor BI-3406
Class: oncoprotein
Keywords: Oncology, exchange factor, protein-ligand complex, ONCOPROTEIN
Deposited on 2019-07-24, released 2020-08-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-02, with a file datestamp of 2021-05-28.
Experiment type: XRAY
Resolution: 1.87 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6scma_
  • Heterogens: L7H, IMD, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6scmA (A:)
geeqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpn
fvrtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyi
qpvqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkki
ardngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqps
elvgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvf
qelnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsi
nppcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclr
vesdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrp
snprpgt

    Sequence, based on observed residues (ATOM records): (download) 
    >6scmA (A:)
eeqmrlpsadvyrfaepdseeniifeenmipiikagtviklierltyhmyadpnfvrtfl
ttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlr
vlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiahnitf
qsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedk
einspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlev
vsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyl
tnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenl
npmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrps