PDB entry 6s79

View 6s79 on RCSB PDB site
Description: Crystal structure of CARM1 in complex with inhibitor AA183
Class: transferase
Keywords: Inhibitor, Complex, Arginine methyltransferase, TRANSFERASE
Deposited on 2019-07-04, released 2020-03-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-11, with a file datestamp of 2020-03-06.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: histone-arginine methyltransferase carm1
    Species: Homo sapiens [TaxId:9606]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6s79a_
  • Chain 'B':
    Compound: histone-arginine methyltransferase carm1
    Species: Homo sapiens [TaxId:9606]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6s79b_
  • Chain 'C':
    Compound: histone-arginine methyltransferase carm1
    Species: Homo sapiens [TaxId:9606]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6s79c_
  • Chain 'D':
    Compound: histone-arginine methyltransferase carm1
    Species: Homo sapiens [TaxId:9606]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6s79d_
  • Heterogens: KXW, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6s79A (A:)
svfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcg
sgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdii
isepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwy
qpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipf
kfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtl
sgtclliankrqsydisivaqvdqtgskssnlldlknpffrytgthhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6s79A (A:)
svfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcg
sgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdii
isepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwy
qpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipf
kfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtl
sgtclliankrqsydisivaqvdqtgskssnlldlknpffry

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6s79B (B:)
svfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcg
sgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdii
isepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwy
qpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipf
kfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtl
sgtclliankrqsydisivaqvdqtgskssnlldlknpffrytgthhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6s79B (B:)
svfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcg
sgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdii
isepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwy
qpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipf
kfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtl
sgtclliankrqsydisivaqvdqtgskssnlldlknpffry

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6s79C (C:)
svfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcg
sgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdii
isepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwy
qpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipf
kfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtl
sgtclliankrqsydisivaqvdqtgskssnlldlknpffrytgthhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6s79C (C:)
svfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcg
sgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdii
isepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwy
qpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipf
kfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtl
sgtclliankrqsydisivaqvdqtgskssnlldlknpffry

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6s79D (D:)
svfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcg
sgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdii
isepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwy
qpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipf
kfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtl
sgtclliankrqsydisivaqvdqtgskssnlldlknpffrytgthhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6s79D (D:)
svfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcg
sgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdii
isepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwy
qpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipf
kfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtl
sgtclliankrqsydisivaqvdqtgskssnlldlknpffry