PDB entry 6s73

View 6s73 on RCSB PDB site
Description: crystal structure of nek7 srs mutant bound to compound 51
Deposited on 2019-07-04, released 2020-06-10
The last revision was dated 2020-06-10, with a file datestamp of 2020-06-05.
Experiment type: XRAY
Resolution: 3.5 Å
R-factor: N/A
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase nek7
    Species: Homo sapiens [TaxId:9606]
    Gene: NEK7
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8TDX7
      • engineered mutation (85)
      • engineered mutation (96)
      • engineered mutation (179)
  • Chain 'B':
    Compound: serine/threonine-protein kinase nek7
    Species: Homo sapiens [TaxId:9606]
    Gene: NEK7
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8TDX7
      • engineered mutation (85)
      • engineered mutation (96)
      • engineered mutation (179)
  • Chain 'C':
    Compound: serine/threonine-protein kinase nek7
    Species: Homo sapiens [TaxId:9606]
    Gene: NEK7
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8TDX7
      • engineered mutation (85)
      • engineered mutation (96)
      • engineered mutation (179)
  • Chain 'D':
    Compound: serine/threonine-protein kinase nek7
    Species: Homo sapiens [TaxId:9606]
    Gene: NEK7
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8TDX7
      • engineered mutation (85)
      • engineered mutation (96)
  • Heterogens: F9N

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6s73A (A:)
mdeqsqgmqgppvpqfqpqkalrpdmgyntlanfriekkigrgqfsevyraaclldgvpv
alkkvqifdlmdakaradcikeidlhkqlnhpnvikfyasfiednelnivleladagdls
rmikhfkkqkrlipertvwkyfvqlcsalehmhsrrvmhrdikpanvfitatgvvklgdf
glgrffsskttaahslvgtpyymsperihengynfksdiwslgcllyemaalqspfygdk
mnlyslckkieqcdypplpsdhyseelrqlvnmcinpdpekrpdvtyvydvakrmhacta
sslehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6s73A (A:)
alrpdmgyntlanfriekkigrgqfsevyraaclldgvpvalkkvqifdlmdakaradci
keidlhkqlnhpnvikfyasfiednelnivleladagdlsrmikhfkkqkrlipertvwk
yfvqlcsalehmhsrrvmhrdikpanvfitatgvvklgdfglgrlvgtpyymsperihen
gynfksdiwslgcllyemaalqspfygdkmnlyslckkieqcdypplpsdhyseelrqlv
nmcinpdpekrpdvtyvydvakrmhacta

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6s73B (B:)
mdeqsqgmqgppvpqfqpqkalrpdmgyntlanfriekkigrgqfsevyraaclldgvpv
alkkvqifdlmdakaradcikeidlhkqlnhpnvikfyasfiednelnivleladagdls
rmikhfkkqkrlipertvwkyfvqlcsalehmhsrrvmhrdikpanvfitatgvvklgdf
glgrffsskttaahslvgtpyymsperihengynfksdiwslgcllyemaalqspfygdk
mnlyslckkieqcdypplpsdhyseelrqlvnmcinpdpekrpdvtyvydvakrmhacta
sslehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6s73B (B:)
kalrpdmgyntlanfriekkigrgqfsevyraaclldgvpvalkkvqifdlmdakaradc
ikeidlhkqlnhpnvikfyasfiednelnivleladagdlsrmikhfkkqkrlipertvw
kyfvqlcsalehmhsrrvmhrdikpanvfitatgvvklgdfglgvgtpyymsperiheng
ynfksdiwslgcllyemaalqspfygdkmnlyslckkieqcdypplpsdhyseelrqlvn
mcinpdpekrpdvtyvydvakrmhacta

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6s73C (C:)
mdeqsqgmqgppvpqfqpqkalrpdmgyntlanfriekkigrgqfsevyraaclldgvpv
alkkvqifdlmdakaradcikeidlhkqlnhpnvikfyasfiednelnivleladagdls
rmikhfkkqkrlipertvwkyfvqlcsalehmhsrrvmhrdikpanvfitatgvvklgdf
glgrffsskttaahslvgtpyymsperihengynfksdiwslgcllyemaalqspfygdk
mnlyslckkieqcdypplpsdhyseelrqlvnmcinpdpekrpdvtyvydvakrmhacta
sslehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6s73C (C:)
mgyntlanfriekkigrgqfsevyraaclldgvpvalkkvqifdlmdakaradcikeidl
hkqlnhpnvikfyasfiednelnivleladagdlsrmikhfkkqkrlipertvwkyfvql
csalehmhsrrvmhrdikpanvfitatgvvklgdfgltpyymsperihengynfksdiws
lgcllyemaalqspfygdkmnlyslckkieqcdypplpsdhyseelrqlvnmcinpdpek
rpdvtyvydvakrmhacta

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6s73D (D:)
mdeqsqgmqgppvpqfqpqkalrpdmgyntlanfriekkigrgqfsevyraaclldgvpv
alkkvqifdlmdakaradcikeidlhkqlnhpnvikfyasfiednelnivleladagdls
rmikhfkkqkrlipertvwkyfvqlcsalehmhsrrvmhrdikpanvfitatgvvklgdf
glgrffsskttaahslvgtpyymsperihengynfksdiwslgcllyemaalqspfygdk
mnlyslckkieqcdypplpsdhyseelrqlvnmcinpdpekrpdvtyvydvakrmhacta
sslehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6s73D (D:)
rpdmgyntlanfriekkigrgqfsevyraaclldgvpvalkkvqifdlmdakaradcike
idlhkqlnhpnvikfyasfiednelnivleladagdlsrmikhfkkqkrlipertvwkyf
vqlcsalehmhsrrvmhrdikpanvfitatgvvklgdtpyymsperihengynfksdiws
lgcllyemaalqspfygdkmnlyslckkieqcdypplpsdhyseelrqlvnmcinpdpek
rpdvtyvydvakrmhacta