PDB entry 6s69

View 6s69 on RCSB PDB site
Description: Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor
Class: transcription
Keywords: TEAD2, Inhibitor, TRANSCRIPTION
Deposited on 2019-07-02, released 2020-07-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-22, with a file datestamp of 2020-07-17.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transcriptional enhancer factor TEF-4
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD2, TEF4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6s69a_
  • Chain 'B':
    Compound: Transcriptional enhancer factor TEF-4
    Species: Homo sapiens [TaxId:9606]
    Gene: TEAD2, TEF4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6s69b_
  • Heterogens: KX5, MYR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6s69A (A:)
mawqarglgtarlqlvefsafveppdavdsyqrhlfvhisqhcpspgapplesvdvrqiy
dkfpekkgglrelydrgpphafflvkfwadlnwgpsgeeagaggsissggfygvssqyes
lehmtltcsskvcsfgkqvvekveteraqledgrfvyrllrspmceylvnflhklrqlpe
rymmnsvlenftilqvvtnrdtqelllctayvfevstsergaqhhiyrlvrdvehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6s69A (A:)
glgtarlqlvefsafveprhlfvhisqlesvdvrqiydkfpekkgglrelydrgpphaff
lvkfwadlnwgfygvssqyeslehmtltcsskvcsfgkqvvekveteraqledgrfvyrl
lrspmceylvnflhklrqlperymmnsvlenftilqvvtnrdtqelllctayvfevstse
rgaqhhiyrlvr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6s69B (B:)
mawqarglgtarlqlvefsafveppdavdsyqrhlfvhisqhcpspgapplesvdvrqiy
dkfpekkgglrelydrgpphafflvkfwadlnwgpsgeeagaggsissggfygvssqyes
lehmtltcsskvcsfgkqvvekveteraqledgrfvyrllrspmceylvnflhklrqlpe
rymmnsvlenftilqvvtnrdtqelllctayvfevstsergaqhhiyrlvrdvehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6s69B (B:)
arglgtarlqlvefsafveppdavdsyqrhlfvhisqhpplesvdvrqiydkfpekkggl
relydrgpphafflvkfwadlnwsggfygvssqyeslehmtltcsskvcsfgkqvvekve
teraqledgrfvyrllrspmceylvnflhklrqlperymmnsvlenftilqvvtnrdtqe
lllctayvfevstsergaqhhiyrlvr