PDB entry 6s2f

View 6s2f on RCSB PDB site
Description: cryo-em structure of ctf18-1-8 in complex with the catalytic domain of dna polymerase epsilon (class 2)
Deposited on 2019-06-20, released 2020-07-08
The last revision was dated 2021-01-20, with a file datestamp of 2021-01-15.
Experiment type: EM
Resolution: 5.8 Å
R-factor: N/A
AEROSPACI score: 0.02 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA polymerase epsilon catalytic subunit A
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: POL2, DUN2, YNL262W, N0825
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21951
      • conflict (316)
      • conflict (318)
  • Chain 'B':
    Compound: Sister chromatid cohesion protein DCC1
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: DCC1, YCL016C, YCL16C
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Chromosome transmission fidelity protein 8
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: CTF8, YHR191C
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Chromosome transmission fidelity protein 18
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: CTF18, CHL12, YMR078C, YM9582.03C
    Database cross-references and differences (RAF-indexed):
  • Heterogens: SF4

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6s2fA (A:)
mkhhhhhhsaglevlfqgpgtgsefelmmfgkkknnggsstarysagnkyntlsnnyals
aqqllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvsqetls
sgsngggnsndgervttnqgisgvdfyfldeeggsfkstvvydpyffiacndesrvndve
elvkkylesclkslqiirkedltmdnhllglqktliklsfvnsnqlfearkllrpilqdn
annnvqrniynvaangsekvdakhliedireydvpyhvrvsidkdirvgkwykvtqqgfi
edtrkiafadpvvmafaiattkpplkfpdsavdqimmisymidgegflitnreiisedie
dfeytpkpeypgfftifnendevallqrffehirdvrptvistfngdffdwpfihnrski
hgldmfdeigfapdaegeykssycshmdcfrwvkrdsylpqgsqglkavtqsklgynpie
ldpelmtpyafekpqhlseysvsdavatyylymkyvhpfifslctiiplnpdetlrkgtg
tlcemllmvqayqhnillpnkhtdpierfydghllesetyvgghvesleagvfrsdlkne
fkidpsaidellqelpealkfsvevenkssvdkvtnfeeiknqitqkllelkennirnel
pliyhvdvasmypnimttnrlqpdsikaerdcascdfnrpgktcarklkwawrgeffpsk
mdeynmikralqnetfpnknkfskkkvltfdelsyadqvihikkrlteysrkvyhrvkvs
eivereaivcqrenpfyvdtvksfrdrryefkglaktwkgnlskidpsdkhardeakkmi
vlydslqlahkvilnsfygyvmrkgsrwysmemagitcltgatiiqmaralvervgrple
ldtdgiwcilpksfpetyfftlengkklylsypcsmlnyrvhqkftnhqyqelkdplnyi
yethsentiffevdgpykamilpsskeegkgikkryavfnedgslaelkgfelkrrgelq
liknfqsdifkvflegdtlegcysavasvcnrwldvldshglmlededlvslicenrsms
ktlkeyegqkstsittarrlgdflgedmvkdkglqckyiisskpfnapvteraipvaifs
adipikrsflrrwtldpsledldirtiidwgyyrerlgsaiqkiitipaalqgvsnpvpr
vehpdwlkrkiatkedkfk

    Sequence, based on observed residues (ATOM records):
    >6s2fA (A:)
alsaqqllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvsqq
gisgvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqiirk
edltmdnhllglqktliklsfvnsnqlfearkllrpilqdireydvpyhvrvsidkdirv
gkwykvtqqgfiedtrkiafadpvvmafaiattkpplkfpdsavdqimmisymidgegfl
itnreiisediedfeytpkpeypgfftifnendevallqrffehirdvrptvistfngdf
fdwpfihnrskihgldmfdeigfapdaegeykssycshmdcfrwvkrdsylpqgsqglka
vtqsklgynpieldpelmtpyafekpqhlseysvsdavatyylymkyvhpfifslctiip
lnpdetlrkgtgtlcemllmvqayqhnillpnkhtdpilesetyvgghvesleagvfrsd
lknefkidpsaidellqelpealkfsvevenkssvdkvtnfeeiknqitqkllelkenni
rnelpliyhvdvasmypnimttnrlqpdsikaerdcascdfnrpgktcarklkwawrgef
vseivereaivcqrenpfyvdtvksfrdrryefkglaktwkgnlskidpsdkhardeakk
mivlydslqlahkvilnsfygyvmrkgsrwysmemagitcltgatiiqmaralvervgrp
leldtdgiwcilpksfpetyfftlengkklylsypcsmlnyrvhqkftnhqyqelkdpln
yiyethsentiffevdgpykamilpsskeegkgikkryavfnedgslaelkgfelkrrge
lqliknfqsdifkvflegdtlegcysavasvcnrwldvldshglmlededlvslicenrs
msktlkstsittarrlgdflgedmvkdkglqckyiisskpfnapvteraipvaifdirti
idwgyyrerlgsaiqkiitipaalqgvsnpvprvehpdwlkrkiat

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6s2fB (B:)
msinlhsapeydpsykliqltpelldiiqdpvqnhqlrfksldkdksevvlcshdktwvl
kqrkhsntvllmrefvpeqpitfdetllfglskpymdvvgfaktesefetrethgelnln
svpiyngeldfsdkimkrsstkvigtleellenspcsalegiskwhkiggsvkdgvlcil
sqdflfkalhvllmsamaesldlqhlnvedthhavgkdiedefnpytreiietvlnkfav
qeqeaenntwrlripfiaqwygiqalrkyvsgismpideflikwkslfppffpcdididm
lrgyhfkptdktvqyiakstlpmdpkerfkvlfrlqsqwdledikplieelnsrgmkids
fimkyarrkrlgkktvvtsr

    Sequence, based on observed residues (ATOM records):
    >6s2fB (B:)
sinlhsapeydpsykliqltpelldiiqdpvqnhqlrfksldkdksevvlcshdktwvlk
qrkhsntvllmrefvpeqpitfdetllfglskpymdvvgfaktesefetrethgelnlns
vpiyngeldfsdkimkrsstkvigtleellenspcsalegiskwhkiggsvkdgvlcils
qdflfkalhvllmsamaesldlqhlnvedthhavgkdiedefnpytreiietvlnkfavq
enntwrlripfiaqwygiqalrkyvsgismpideflikwkslfppffpcdididmlrgyh
fkptdktvqyiakstlpmdpkerfkvlfrlqsqwdledikplieelnsrgmkidsfimky
arrkrlgkktvvtsr

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6s2fD (D:)
mpsvdidasqwqkltqsrekqttvitplgmmmleiqgelelpkdfaslarrdspnegrfs
eqdgetlirfgslqidgeratlfvgkkqrllgkvtkldvpmgimhfnskdnkvelvdvmk
ykvifkdrplpim

    Sequence, based on observed residues (ATOM records):
    >6s2fD (D:)
psvdidasqwqkltqsrekqttvitplgmmmleiqgelelpkdfaslarrdspnegrfse
qdgetlirfgslqidgeratlfvgkkqrllgkvtkldvpmgimhfnskdnkvelvdvmky
kvifkdrplpim

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6s2fE (E:)
gamgnqtvkiwvkynegfsnavrknvtwnnlwe

    Sequence, based on observed residues (ATOM records):
    >6s2fE (E:)
tvkiwvkynegfsnavrknvtwnnlw