PDB entry 6s25

View 6s25 on RCSB PDB site
Description: Crystal Structure of the first bromodomain of BRD4 in complex with a benzodiazepine ligand
Class: transcription
Keywords: BET, Bromodomain, RT53, inhibitor, Structural Genomics, Structural Genomics Consortium, SGC, TRANSCRIPTION
Deposited on 2019-06-20, released 2019-07-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-31, with a file datestamp of 2019-07-26.
Experiment type: XRAY
Resolution: 1.1 Å
R-factor: N/A
AEROSPACI score: 0.74 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (2-126)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d6s25a1, d6s25a2
  • Heterogens: KSZ, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6s25A (A:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee