PDB entry 6s1o

View 6s1o on RCSB PDB site
Description: human polymerase delta holoenzyme conformer 3
Deposited on 2019-06-19, released 2019-12-25
The last revision was dated 2020-03-11, with a file datestamp of 2020-03-06.
Experiment type: EM
Resolution: 8.1 Å
R-factor: N/A
AEROSPACI score: -0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA polymerase delta catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: POLD1, POLD
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: DNA polymerase delta subunit 2
    Species: Homo sapiens [TaxId:9606]
    Gene: POLD2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: DNA polymerase delta subunit 3
    Species: Homo sapiens [TaxId:9606]
    Gene: POLD3, KIAA0039
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: DNA polymerase delta subunit 4
    Species: Homo sapiens [TaxId:9606]
    Gene: POLD4, POLDS
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Proliferating Cell Nuclear Antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: PCNA
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Proliferating Cell Nuclear Antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: PCNA
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Proliferating Cell Nuclear Antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: PCNA
    Database cross-references and differences (RAF-indexed):
  • Chain 'P':
    Compound: DNA Primer
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'T':
    Compound: DNA Template
    Species: synthetic construct, synthetic [TaxId:32630]
  • Heterogens: ZN, SF4, TTP

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6s1oA (A:)
mdgkrrpgpgpgvppkrargglwddddaprpsqfeedlalmeemeaehrlqeqeeeelqs
vlegvadgqvppsaidprwlrptppaldpqteplifqqleidhyvgpaqpvpggpppsrg
svpvlrafgvtdegfsvcchihgfapyfytpappgfgpehmgdlqrelnlaisrdsrggr
eltgpavlavelcsresmfgyhghgpspflritvalprlvaparrlleqgirvaglgtps
fapyeanvdfeirfmvdtdivgcnwlelpagkyalrlkekatqcqleadvlwsdvvshpp
egpwqriaplrvlsfdiecagrkgifpeperdpviqicslglrwgepepflrlaltlrpc
apilgakvqsyekeedllqawstfirimdpdvitgyniqnfdlpylisraqtlkvqtfpf
lgrvaglcsnirdssfqskqtgrrdtkvvsmvgrvqmdmlqvllreyklrsytlnavsfh
flgeqkedvqhsiitdlqngndqtrrrlavyclkdaylplrllerlmvlvnavemarvtg
vplsyllsrgqqvkvvsqllrqamhegllmpvvkseggedytgatvieplkgyydvpiat
ldfsslypsimmahnlcyttllrpgtaqklgltedqfirtptgdefvktsvrkgllpqil
enllsarkrakaelaketdplrrqvldgrqlalkvsansvygftgaqvgklpcleisqsv
tgfgrqmiektkqlveskytvengystsakvvygdtdsvmcrfgvssvaeamalgreaad
wvsghfpspirlefekvyfpylliskkryagllfssrpdahdrmdckgleavrrdncplv
anlvtaslrrllidrdpegavahaqdvisdllcnridisqlvitkeltraasdyagkqah
velaermrkrdpgsapslgdrvpyviisaakgvaaymksedplfvlehslpidtqyyleq
qlakpllrifepilgegraeavllrgdhtrcktvltgkvggllafakrrnccigcrtvls
hqgavcefcqpreselyqkevshlnaleerfsrlwtqcqrcqgslhedvictsrdcpify
mrkkvrkdledqeqllrrfgppgpeaw

    Sequence, based on observed residues (ATOM records):
    >6s1oA (A:)
rwlrptppaldpqteplifqqleidhyvgpaqpvsvpvlrafgvtdegfsvcchihgfap
yfytpappgfgpehmgdlqrelnlaisrdsrggreltgpavlavelcsresmfgyhghgp
spflritvalprlvaparrlleqgirvaglgtpsfapyeanvdfeirfmvdtdivgcnwl
elpagkyalrlkekatqcqleadvlwsdvvshppegpwqriaplrvlsfdiecagrkgif
peperdpviqicslglrwgepepflrlaltlrpcapilgakvqsyekeedllqawstfir
imdpdvitgyniqnfdlpylisraqtlkvqtfpflgrvaglcsnirdssfqskqtgrrdt
kvvsmvgrvqmdmlqvllreyklrsytlnavsfhflgehsiitdlqngndqtrrrlavyc
lkdaylplrllerlmvlvnavemarvtgvplsyllsrgqqvkvvsqllrqamhegllmpv
vkseggedytgatvieplkgyydvpiatldfsslypsimmahnlcyttllrpgtaqklgl
tedqfirtptgdefvktsvrkgllpqilenllsarkrakaelaketdplrrqvldgrqla
lkvsansvygftgaqvgklpcleisqsvtgfgrqmiektkqlveskytvengystsakvv
ygdtdsvmcrfgvssvaeamalgreaadwvsghfpspirlefekvyfpylliskkryagl
lfssrpdahdrmdckgleavrrdncplvanlvtaslrrllidrdpegavahaqdvisdll
cnridisqlvitkeltraasdyagkqahvelaermrkrdpgsapslgdrvpyviisaakg
vaaymksedplfvlehslpidtqyyleqqlakpllrifepilgegraeavllrgdhtrck
tvlgllafakrrnccigcrtvlshqgavcefcqpreselyqkevshlnaleerfsrlwtq
cqrcqgslhedvictsrdcpifymrkkvrkdledqeqllrrfgppgpeaw

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6s1oB (B:)
mfseqaaqrahtllsppsannatfarvpvatytnssqpfrlgersfsrqyahiyatrliq
mrpflenraqqhwgsgvgvkklcelqpeekccvvgtlfkamplqpsilrevseehnllpq
pprskyihpddelvledelqriklkgtidvsklvtgtvlavfgsvrddgkflvedycfad
lapqkpappldtdrfvllvsglglgggggesllgtqllvdvvtgqlgdegeqcsaahvsr
vilagnllshstqsrdsinkakyltkktqaasveavkmldeillqlsasvpvdvmpgefd
ptnytlpqqplhpcmfplataystlqlvtnpyqatidgvrflgtsgqnvsdifryssmed
hleilewtlrvrhisptapdtlgcypfyktdpfifpecphvyfcgntpsfgskiirgped
qtvllvtvpdfsatqtaclvnlrslacqpisfsgfgaedddlgglglgp

    Sequence, based on observed residues (ATOM records):
    >6s1oB (B:)
mfseqaaqrahtllsppsannatfarvpvatytnssqpfrlgersfsrqyahiyatrliq
mrpflenraqqhwgsgvgvkklcelqpeekccvvgtlfkamplqpsilskyihpddelvl
edelqriklkgtidvsklvtgtvlavfgsvrddgkflvedycfadlapqkpappldtdrf
vllvsglglgggggesllgtqllvdvvtgqlgdegeqcsaahvsrvilagnllshstqsa
sveavkmldeillqlsasvpvdvmpgefdptnytlpqqplhpcmfplataystlqlvtnp
yqatidgvrflgtsgqnvsdifryssmedhleilewtlrvrhisptapdtlgcypfyktd
pfifpecphvyfcgntpsfgskiirgpedqtvllvtvpdfsatqtaclvnlrslacqpis
fsgfgaedddl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6s1oC (C:)
mwshpqfekadqlylenidefvtdqnkivtykwlsytlgvhvnqakqmlydyverkrken
sgaqlhvtylvsgsliqnghschkvavvredkleavksklavtasihvysiqkamlkdsg
plfntdydilksnlqncskfsaiqcaaavprapaessssskkfeqshlhmssetqannel
ttnghgppaskqvsqqpkgimgmfaskaaaktqetnketkteakevtnasaagnkapgkg
nmmsnffgkaamnkfkvnldseqavkeekiveqptvsvtepklatpaglkksskkaepvk
vlqkekkrgkrvalsddetketenmrkkrrriklpesdssedevfpdspgayeaespspp
pppspplepvpktepeppsvksssgenkrkrkrvlksktyldgegcivtekvyesesctd
seeelnmktssvhrppamtvkkepreerkgpkkgtaalgkanrqvsitgffqrk

    Sequence, based on observed residues (ATOM records):
    >6s1oC (C:)
adqlylenidefvtdqnkivtykwlsytlgvhvnqakqmlydyverkrkensgaqlhvty
lvsgsliqnghschkvavvredkleavksklavtasihvysiqkamlkdsgplfntdydi
lksnlqncskfsaiqcaaavpra

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6s1oD (D:)
mhhhhhhsrawrhpqfgghhhhhhenlyfqsgrkrlitdsypvvkrregpaghskgelap
elgeepqprdeeeaelellrqfdlawqygpctgitrlqrwcrakqmglepppevwqvlkt
hpgdprfqcslwhlypl

    Sequence, based on observed residues (ATOM records):
    >6s1oD (D:)
eeaelellrqfdlawqygpctgitrlqrwcrakqmglepppevwqvlkthpgdprfqcsl
whlypl

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6s1oE (E:)
gphmfearlvqgsilkkvlealkdlineacwdisssgvnlqsmdsshvslvqltlrsegf
dtyrcdrnlamgvnltsmskilkcagnediitlraednadtlalvfeapnqekvsdyemk
lmdldveqlgipeqeyscvvkmpsgefaricrdlshigdavviscakdgvkfsasgelgn
gniklsqtsnvdkeeeavtiemnepvqltfalrylnfftkatplsstvtlsmsadvplvv
eykiadmghlkyylapkiedeegs

    Sequence, based on observed residues (ATOM records):
    >6s1oE (E:)
mfearlvqgsilkkvlealkdlineacwdisssgvnlqsmdsshvslvqltlrsegfdty
rcdrnlamgvnltsmskilkcagnediitlraednadtlalvfeapnqekvsdyemklmd
ldveqlgipeqeyscvvkmpsgefaricrdlshigdavviscakdgvkfsasgelgngni
klsqtseeeavtiemnepvqltfalrylnfftkatplsstvtlsmsadvplvveykiadm
ghlkyylapki

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6s1oF (F:)
gphmfearlvqgsilkkvlealkdlineacwdisssgvnlqsmdsshvslvqltlrsegf
dtyrcdrnlamgvnltsmskilkcagnediitlraednadtlalvfeapnqekvsdyemk
lmdldveqlgipeqeyscvvkmpsgefaricrdlshigdavviscakdgvkfsasgelgn
gniklsqtsnvdkeeeavtiemnepvqltfalrylnfftkatplsstvtlsmsadvplvv
eykiadmghlkyylapkiedeegs

    Sequence, based on observed residues (ATOM records):
    >6s1oF (F:)
mfearlvqgsilkkvlealkdlineacwdisssgvnlqsmdsshvslvqltlrsegfdty
rcdrnlamgvnltsmskilkcagnediitlraednadtlalvfeapnekvsdyemklmdl
dveqlgipeqeyscvvkmpsgefaricrdlshigdavviscakdgvkfsasgelgngnik
lsqteeeavtiemnepvqltfalrylnfftkatplsstvtlsmsadvplvveykiadmgh
lkyylapki

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6s1oG (G:)
gphmfearlvqgsilkkvlealkdlineacwdisssgvnlqsmdsshvslvqltlrsegf
dtyrcdrnlamgvnltsmskilkcagnediitlraednadtlalvfeapnqekvsdyemk
lmdldveqlgipeqeyscvvkmpsgefaricrdlshigdavviscakdgvkfsasgelgn
gniklsqtsnvdkeeeavtiemnepvqltfalrylnfftkatplsstvtlsmsadvplvv
eykiadmghlkyylapkiedeegs

    Sequence, based on observed residues (ATOM records):
    >6s1oG (G:)
mfearlvqgsilkkvlealkdlineacwdisssgvnlqsmdsshvslvqltlrsegfdty
rcdrnlamgvnltsmskilkcagnediitlraednadtlalvfeapnqekvsdyemklmd
ldveqlgipeqeyscvvkmpsgefaricrdlshigdavviscakdgvkfsasgelgngni
klsqtseavtiemnepvqltfalrylnfftkatplsstvtlsmsadvplvveykiadmgh
lkyylapki

  • Chain 'P':
    No sequence available.

  • Chain 'T':
    No sequence available.