PDB entry 6s1c

View 6s1c on RCSB PDB site
Description: p3221 crystal form of the ctf18-1-8/pol2(1-528) complex
Deposited on 2019-06-18, released 2020-07-08
The last revision was dated 2021-01-20, with a file datestamp of 2021-01-15.
Experiment type: XRAY
Resolution: 6.1 Å
R-factor: N/A
AEROSPACI score: 0.04 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA polymerase epsilon catalytic subunit A
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: POL2, DUN2, YNL262W, N0825
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21951 (Start-548)
      • engineered mutation (314)
      • engineered mutation (316)
  • Chain 'B':
    Compound: Sister chromatid cohesion protein DCC1
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: DCC1, YCL016C, YCL16C
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Chromosome transmission fidelity protein 8
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: CTF8, YHR191C
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Chromosome transmission fidelity protein 18
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: CTF18, CHL12, YMR078C, YM9582.03C
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: DNA polymerase epsilon catalytic subunit A
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: POL2, DUN2, YNL262W, N0825
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21951 (Start-548)
      • engineered mutation (314)
      • engineered mutation (316)
  • Chain 'F':
    Compound: Sister chromatid cohesion protein DCC1
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: DCC1, YCL016C, YCL16C
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Chromosome transmission fidelity protein 8
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: CTF8, YHR191C
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Chromosome transmission fidelity protein 18
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: CTF18, CHL12, YMR078C, YM9582.03C
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6s1cA (A:)
mkhhhhhhsaglevlfqgpgtgsefmmfgkkknnggsstarysagnkyntlsnnyalsaq
qllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvsqetlssg
sngggnsndgervttnqgisgvdfyfldeeggsfkstvvydpyffiacndesrvndveel
vkkylesclkslqiirkedltmdnhllglqktliklsfvnsnqlfearkllrpilqdnan
nnvqrniynvaangsekvdakhliedireydvpyhvrvsidkdirvgkwykvtqqgfied
trkiafadpvvmafaiattkpplkfpdsavdqimmisymidgegflitnreiisediedf
eytpkpeypgfftifnendevallqrffehirdvrptvistfngdffdwpfihnrskihg
ldmfdeigfapdaegeykssycshmdcfrwvkrdsylpqgsqglkavtqsklgynpield
pelmtpyafekpqhlseysvsdavatyylymkyvhpfifslctiiplnpdetlrkgtgtl
cemllmvqa

    Sequence, based on observed residues (ATOM records):
    >6s1cA (A:)
nyalsaqqllnaskiddidsmmgferyvppqgwltnmhatlvsqetttnqgisgvdfyfl
deeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqiirkedlklsfvns
nqlfearkllrpilqdnahliedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrk
iafadpvvmafaiattkpplkfpdsavdqimmisymidgegflitnreiisediedfeyt
pkpeypgfftifnendevallqrffehirdvrptvistfngdffdwpfihnrskihgldm
fdeigfapdaegeykssycshmdcfrwvkrdsylpqgsqglkavtqsklgynpieldpel
mtpyafekpqhlseysvsdavatyylymkyvhpfifslctiiplnpdetlrkgtgtlcem
llmvqa

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6s1cB (B:)
msinlhsapeydpsykliqltpelldiiqdpvqnhqlrfksldkdksevvlcshdktwvl
kqrkhsntvllmrefvpeqpitfdetllfglskpymdvvgfaktesefetrethgelnln
svpiyngeldfsdkimkrsstkvigtleellenspcsalegiskwhkiggsvkdgvlcil
sqdflfkalhvllmsamaesldlqhlnvedthhavgkdiedefnpytreiietvlnkfav
qeqeaenntwrlripfiaqwygiqalrkyvsgismpideflikwkslfppffpcdididm
lrgyhfkptdktvqyiakstlpmdpkerfkvlfrlqsqwdledikplieelnsrgmkids
fimkyarrkrlgkktvvtsr

    Sequence, based on observed residues (ATOM records):
    >6s1cB (B:)
sinlhsapeydpsykliqltpelldiiqdpvqnhqlrfksldkdksevvlcshdktwvlk
qrkhsntvllmrefvpeqpitfdetllfglskpymdvvgfaktesefetrethgelnlns
vigtleellenspcsalegiskwhkiggscilsqdflfkalhvllmsamaesldlqhlnv
edthhavgkdiedefnpytreiietvlnkfavqtwrlripfiaqwygiqalrkyvsgism
pideflikwkslfppffpcdididmlrgyhfkktvqyiakstlpmdpkerfkvlfrlqsq
wdledikplieelnsrgmkidsfimkyarrkrlgkktvvtsr

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6s1cC (C:)
mpsvdidasqwqkltqsrekqttvitplgmmmleiqgelelpkdfaslarrdspnegrfs
eqdgetlirfgslqidgeratlfvgkkqrllgkvtkldvpmgimhfnskdnkvelvdvmk
ykvifkdrplpim

    Sequence, based on observed residues (ATOM records):
    >6s1cC (C:)
psvdidasqwqkltqsrekqttvitplgmmmleiqgelelpkdfaslarrdspnegrfse
qdgetlirfgslqidgeratlfvgkkqrllgkvtkldvpmgimhfnskdnkvelvdvmky
kvifkdrplpi

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6s1cD (D:)
gamgnqtvkiwvkynegfsnavrknvtwnnlwe

    Sequence, based on observed residues (ATOM records):
    >6s1cD (D:)
iwvkynegfsnavrknvtwnnlwe

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6s1cE (E:)
mkhhhhhhsaglevlfqgpgtgsefmmfgkkknnggsstarysagnkyntlsnnyalsaq
qllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvsqetlssg
sngggnsndgervttnqgisgvdfyfldeeggsfkstvvydpyffiacndesrvndveel
vkkylesclkslqiirkedltmdnhllglqktliklsfvnsnqlfearkllrpilqdnan
nnvqrniynvaangsekvdakhliedireydvpyhvrvsidkdirvgkwykvtqqgfied
trkiafadpvvmafaiattkpplkfpdsavdqimmisymidgegflitnreiisediedf
eytpkpeypgfftifnendevallqrffehirdvrptvistfngdffdwpfihnrskihg
ldmfdeigfapdaegeykssycshmdcfrwvkrdsylpqgsqglkavtqsklgynpield
pelmtpyafekpqhlseysvsdavatyylymkyvhpfifslctiiplnpdetlrkgtgtl
cemllmvqa

    Sequence, based on observed residues (ATOM records):
    >6s1cE (E:)
nyalsaqqllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvs
qegisgvdfyfldeeggsfkstvvydpyvndveelvkkylesclkssfvnsnqlfearkl
ydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafaiattkpplkfpdsa
vdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnendevallqrffe
hirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykssycshmdcfr
wvkrdsylpqgsqglkavtqsklgynpieldpelmtpyafekpqhlseysvsdavatyyl
ymkyvhpfifslctiiplnpdetlrkgtgtlcemllmvqa

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6s1cF (F:)
msinlhsapeydpsykliqltpelldiiqdpvqnhqlrfksldkdksevvlcshdktwvl
kqrkhsntvllmrefvpeqpitfdetllfglskpymdvvgfaktesefetrethgelnln
svpiyngeldfsdkimkrsstkvigtleellenspcsalegiskwhkiggsvkdgvlcil
sqdflfkalhvllmsamaesldlqhlnvedthhavgkdiedefnpytreiietvlnkfav
qeqeaenntwrlripfiaqwygiqalrkyvsgismpideflikwkslfppffpcdididm
lrgyhfkptdktvqyiakstlpmdpkerfkvlfrlqsqwdledikplieelnsrgmkids
fimkyarrkrlgkktvvtsr

    Sequence, based on observed residues (ATOM records):
    >6s1cF (F:)
sinlhsapeydpsykliqltpelldiiqdpvqnhqlrfksldkdksevvlcshdktwvlk
qrkhsntvllmrefvpeqpitfdetllfglskpymdvvgfaktesefetrethgelnlns
vigtleellenspcsalegiskwhkiggscilsqdflfkalhvllmsamaesllripfia
qwygiqalrkyvsgismpideflikwkslfppffpcdididmlrgyhfkktvqyiakstl
pmdpkerfkvlfrlqsqwdledikplieelnsrgmkidsfimkyarrkrlgkktvvtsr

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6s1cG (G:)
mpsvdidasqwqkltqsrekqttvitplgmmmleiqgelelpkdfaslarrdspnegrfs
eqdgetlirfgslqidgeratlfvgkkqrllgkvtkldvpmgimhfnskdnkvelvdvmk
ykvifkdrplpim

    Sequence, based on observed residues (ATOM records):
    >6s1cG (G:)
psvdidasqwqkltqsrekqttvitplgmmmleiqgelelpkdfaslarrdspnegrfse
qdgetlirfgslqidgeratlfvgkkqrllgkvtkldvpmgimhfnskdnkvelvdvmky
kvifkdrplpi

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6s1cH (H:)
gamgnqtvkiwvkynegfsnavrknvtwnnlwe

    Sequence, based on observed residues (ATOM records):
    >6s1cH (H:)
iwvkynegfsnavrknvtwnnlwe