PDB entry 6s14

View 6s14 on RCSB PDB site
Description: Crystal Structure of DYRK1A with small molecule inhibitor
Class: transferase
Keywords: Kinase, catalytic domain, phosphorylated, TRANSFERASE
Deposited on 2019-06-18, released 2019-06-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-08-21, with a file datestamp of 2019-08-16.
Experiment type: XRAY
Resolution: 1.05 Å
R-factor: N/A
AEROSPACI score: 0.77 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6s14a_
  • Heterogens: KQW, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6s14A (A:)
smsshkkerkvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqew
vaikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsyn
lydllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaik
ivdfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsga
nevdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrklh
nilgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffkktad
e

    Sequence, based on observed residues (ATOM records): (download) 
    >6s14A (A:)
vyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknkk
aflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntnf
rgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscql
gqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnkiv
evlgippahildqapkarkffeklpdgtwnlkkykppgtrklhnilgvetggpggrrage
sghtvadylkfkdlilrmldydpktriqpyyalqhsffkk