PDB entry 6rwo

View 6rwo on RCSB PDB site
Description: SIVrcm intasome (Q148/G140S) in complex with bictegravir
Class: recombination
Keywords: retroviral integrase, lentivirus, strand transfer inhibior, protein-DNA complex, RECOMBINATION
Deposited on 2019-06-05, released 2020-02-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-02-05, with a file datestamp of 2020-01-31.
Experiment type: EM
Resolution: 3.05 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8 (1-End)
      • expression tag (0)
      • engineered mutation (119)
      • engineered mutation (140)
      • engineered mutation (148)
  • Chain 'B':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8 (1-End)
      • engineered mutation (119)
      • engineered mutation (140)
  • Chain 'C':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8
      • engineered mutation (119)
      • engineered mutation (140)
    Domains in SCOPe 2.07: d6rwoc1, d6rwoc2
  • Chain 'D':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8
      • engineered mutation (119)
      • engineered mutation (140)
    Domains in SCOPe 2.07: d6rwod1, d6rwod2
  • Chain 'E':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.07: d6rwoe1, d6rwoe2
  • Chain 'F':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6rwof1
  • Chain 'I':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8 (1-End)
      • expression tag (0)
      • engineered mutation (119)
      • engineered mutation (140)
      • engineered mutation (148)
  • Chain 'J':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8 (1-End)
      • engineered mutation (119)
      • engineered mutation (140)
  • Chain 'K':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8
      • engineered mutation (119)
      • engineered mutation (140)
    Domains in SCOPe 2.07: d6rwok1, d6rwok2
  • Chain 'L':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8
      • engineered mutation (119)
      • engineered mutation (140)
    Domains in SCOPe 2.07: d6rwol1, d6rwol2
  • Chain 'M':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.07: d6rwom1, d6rwom2
  • Chain 'N':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6rwon1
  • Chain 'Q':
    Compound: DNA (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3')
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: U5 LTR end
  • Chain 'S':
    Compound: DNA (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3')
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: U5 LTR end
  • Chain 'T':
    Compound: DNA (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3')
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: U5 LTR end
  • Chain 'W':
    Compound: DNA (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3')
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: U5 LTR end
  • Heterogens: KLQ, ZN, CL, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6rwoC (C:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfsvpynpqshgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwoC (C:)
giekaqeehekyhnnwramaedfqipqvvakeivaqcpkcspktwqmdcthlegkviiva
vhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngdnftssavqavcwwaqie
htfsgvvesmnhqlktiitqirdqaekietavqmavlihnfkrkggiggysageriidii
asdlqttklqnqi

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6rwoD (D:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfsvpynpqshgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwoD (D:)
spktwqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtd
ngdnftssavqavcwwaqiehtfsvvesmnhqlktiitqirdqaekietavqmavlihnf
krkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpatliwkg
egavviqdgqdlkvvprrkckiikdyg

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6rwoE (E:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfsvpynpqshgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwoE (E:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6rwoF (F:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfsvpynpqshgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwoF (F:)
iiasdlqttklqnqiskiqnfrvyfregrdqqwkgpatliwkgegavviqdgqdlkvvpr
rkckiikdy

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >6rwoK (K:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfsvpynpqshgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwoK (K:)
giekaqeehekyhnnwramaedfqipqvvakeivaqcpkcspktwqmdcthlegkviiva
vhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngdnftssavqavcwwaqie
htfsgvvesmnhqlktiitqirdqaekietavqmavlihnfkrkggiggysageriidii
asdlqttklqnqi

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6rwoL (L:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfsvpynpqshgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwoL (L:)
spktwqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtd
ngdnftssavqavcwwaqiehtfsvvesmnhqlktiitqirdqaekietavqmavlihnf
krkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpatliwkg
egavviqdgqdlkvvprrkckiikdyg

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >6rwoM (M:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfsvpynpqshgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwoM (M:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvk

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >6rwoN (N:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfsvpynpqshgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwoN (N:)
iiasdlqttklqnqiskiqnfrvyfregrdqqwkgpatliwkgegavviqdgqdlkvvpr
rkckiikdy

  • Chain 'Q':
    No sequence available.

  • Chain 'S':
    No sequence available.

  • Chain 'T':
    No sequence available.

  • Chain 'W':
    No sequence available.