PDB entry 6rwn

View 6rwn on RCSB PDB site
Description: SIVrcm intasome in complex with dolutegravir
Class: recombination
Keywords: retroviral integrase, lentivirus, strand transfer inhibior, protein-DNA complex, RECOMBINATION
Deposited on 2019-06-05, released 2020-02-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-02-05, with a file datestamp of 2020-01-31.
Experiment type: EM
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8 (1-End)
      • expression tag (0)
      • engineered mutation (119)
  • Chain 'B':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8 (1-End)
      • engineered mutation (119)
  • Chain 'C':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8
      • engineered mutation (119)
    Domains in SCOPe 2.07: d6rwnc1, d6rwnc2
  • Chain 'D':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8
      • engineered mutation (119)
    Domains in SCOPe 2.07: d6rwnd1, d6rwnd2
  • Chain 'E':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.07: d6rwne1, d6rwne2
  • Chain 'F':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6rwnf1
  • Chain 'I':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8 (1-End)
      • expression tag (0)
      • engineered mutation (119)
  • Chain 'J':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8 (1-End)
      • engineered mutation (119)
  • Chain 'K':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8
      • engineered mutation (119)
    Domains in SCOPe 2.07: d6rwnk1, d6rwnk2
  • Chain 'L':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8
      • engineered mutation (119)
    Domains in SCOPe 2.07: d6rwnl1, d6rwnl2
  • Chain 'M':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1ANT8 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.07: d6rwnm1, d6rwnm2
  • Chain 'N':
    Compound: pol protein
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: pol
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6rwnn1
  • Chain 'Q':
    Compound: DNA (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3')
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: U5 LTR vDNA end
  • Chain 'S':
    Compound: DNA (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3')
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: U5 LTR vDNA end
  • Chain 'T':
    Compound: DNA (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3')
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: U5 LTR vDNA end
  • Chain 'W':
    Compound: DNA (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3')
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: U5 LTR vDNA end
  • Heterogens: DLU, ZN, CL, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6rwnC (C:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfgvpynpqsqgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwnC (C:)
giekaqeehekyhnnwramaedfqipqvvakeivaqcpkcspktwqmdcthlegkviiva
vhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngdnftssavqavcwwaqie
htfggvvesmnhqlktiitqirdqaekietavqmavlihnfkrkggiggysageriidii
asdlqttklqnqi

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6rwnD (D:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfgvpynpqsqgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwnD (D:)
spktwqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtd
ngdnftssavqavcwwaqiehtfgvvesmnhqlktiitqirdqaekietavqmavlihnf
krkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpatliwkg
egavviqdgqdlkvvprrkckiikdyg

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6rwnE (E:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfgvpynpqsqgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwnE (E:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6rwnF (F:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfgvpynpqsqgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwnF (F:)
iiasdlqttklqnqiskiqnfrvyfregrdqqwkgpatliwkgegavviqdgqdlkvvpr
rkckiikdy

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >6rwnK (K:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfgvpynpqsqgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwnK (K:)
giekaqeehekyhnnwramaedfqipqvvakeivaqcpkcspktwqmdcthlegkviiva
vhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngdnftssavqavcwwaqie
htfggvvesmnhqlktiitqirdqaekietavqmavlihnfkrkggiggysageriidii
asdlqttklqnqi

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6rwnL (L:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfgvpynpqsqgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwnL (L:)
spktwqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtd
ngdnftssavqavcwwaqiehtfgvvesmnhqlktiitqirdqaekietavqmavlihnf
krkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpatliwkg
egavviqdgqdlkvvprrkckiikdyg

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >6rwnM (M:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfgvpynpqsqgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwnM (M:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvk

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >6rwnN (N:)
gfldgiekaqeehekyhnnwramaedfqipqvvakeivaqcpkcqvkgeamhgqvdaspk
twqmdcthlegkviivavhvasgyieaevlpaetgketahfllklaarwpvkhlhtdngd
nftssavqavcwwaqiehtfgvpynpqsqgvvesmnhqlktiitqirdqaekietavqma
vlihnfkrkggiggysageriidiiasdlqttklqnqiskiqnfrvyfregrdqqwkgpa
tliwkgegavviqdgqdlkvvprrkckiikdygrkdvdsetsmegrqekd

    Sequence, based on observed residues (ATOM records): (download) 
    >6rwnN (N:)
iiasdlqttklqnqiskiqnfrvyfregrdqqwkgpatliwkgegavviqdgqdlkvvpr
rkckiikdy

  • Chain 'Q':
    No sequence available.

  • Chain 'S':
    No sequence available.

  • Chain 'T':
    No sequence available.

  • Chain 'W':
    No sequence available.