PDB entry 6rtw

View 6rtw on RCSB PDB site
Description: Crystal structure of the Patched-1 (PTCH1) ectodomain in complex with nanobody NB64 and cholesterol-hemisuccinate
Class: membrane protein
Keywords: ---- Hedgehog morphogen receptor, receptor-nanobody complex, cholesterol, palmitate, lipid-protein-modification, MEMBRANE PROTEIN
Deposited on 2019-05-27, released 2019-10-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein patched homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTCH1, PTCH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13635 (Start-287)
      • expression tag (288-289)
  • Chain 'B':
    Compound: Llama-derived nanobody NB64
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RTW (0-End)
    Domains in SCOPe 2.08: d6rtwb1, d6rtwb2, d6rtwb3
  • Heterogens: Y01, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6rtwB (B:)
qvqlqesggglvqpggslrlscaasgsgnsinvmgwyrqapgkprelvaeitssgttnya
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    Sequence, based on observed residues (ATOM records): (download) 
    >6rtwB (B:)
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dsvkgrfsisrdnakntvplqmnslkpedtaiyycsavlvrfgglrrsywgqgtqvtvss
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