PDB entry 6rsy

View 6rsy on RCSB PDB site
Description: The complex between TCR a7b2 and human Class I MHC HLA-A0201-WT1 with the bound RMFPNAPYL peptide.
Class: immune system
Keywords: MHC CLASS I ANTIGEN- TCR - peptide complex, IMMUNE SYSTEM
Deposited on 2019-05-22, released 2020-04-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-05-13, with a file datestamp of 2020-05-08.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6rsya1, d6rsya2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d6rsyb1, d6rsyb2
  • Chain 'C':
    Compound: arg-met-phe-pro-asn-ala-pro-tyr-leu
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RSY (0-8)
  • Chain 'D':
    Compound: a7b2 ALPHA CHAIN
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RSY
    Domains in SCOPe 2.08: d6rsyd1, d6rsyd2
  • Chain 'E':
    Compound: DMF4 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RSY (Start-244)
    Domains in SCOPe 2.08: d6rsye1, d6rsye2
  • Chain 'F':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6rsyf1, d6rsyf2
  • Chain 'G':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d6rsyg1, d6rsyg2
  • Chain 'H':
    Compound: arg-met-phe-pro-asn-ala-pro-tyr-leu
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RSY (0-8)
  • Chain 'I':
    Compound: a7b2 ALPHA CHAIN
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RSY
    Domains in SCOPe 2.08: d6rsyi1, d6rsyi2
  • Chain 'J':
    Compound: DMF4 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RSY (Start-244)
    Domains in SCOPe 2.08: d6rsyj1, d6rsyj2
  • Heterogens: EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6rsyA (A:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwep

    Sequence, based on observed residues (ATOM records): (download) 
    >6rsyA (A:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwe

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6rsyB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6rsyD (D:)
madakttqppsmdcaegraanlpcnhstvdpneyvywyrqihsqgpqyiihglknnetne
masliitedrksstlilphatlrdtavyycigggttsgtykyifgtgtrlkvlaniqnpd
pavyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavaws
nksdfacanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >6rsyD (D:)
dakttqppsmdcaegraanlpcnhstvdpneyvywyrqihsqgpqyiihglknnetnema
sliitedrksstlilphatlrdtavyycigggttsgtykyifgtgtrlkvlaniqnpdpa
vyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnk
sdfacanafnns

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6rsyE (E:)
mdtgvsqdprhkitkrgqnvtfrcdpisehnrlywyrqtlgqgpefltyfqneaqleksr
llsdrfsaerpkgsfstleiqrteqgdsamylcasslgfgrdvmrfgpgtrllvledlkn
vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
qpalndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaet
wgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >6rsyE (E:)
gvsqdprhkitkrgqnvtfrcdpisehnrlywyrqtlgqgpefltyfqneaqleksrlls
drfsaerpkgsfstleiqrteqgdsamylcasslgfgrdvmrfgpgtrllvledlknvfp
pevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpa
lndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaetwgr
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  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6rsyF (F:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrwep

    Sequence, based on observed residues (ATOM records): (download) 
    >6rsyF (F:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgqeqrytchvqheglpkpltlrw

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6rsyG (G:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >6rsyI (I:)
madakttqppsmdcaegraanlpcnhstvdpneyvywyrqihsqgpqyiihglknnetne
masliitedrksstlilphatlrdtavyycigggttsgtykyifgtgtrlkvlaniqnpd
pavyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavaws
nksdfacanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >6rsyI (I:)
adakttqppsmdcaegraanlpcnhstvdpneyvywyrqihsqgpqyiihglknnetnem
asliitedrksstlilphatlrdtavyycigggttsgtykyifgtgtrlkvlaniqnpdp
avyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsn
ksdfacanafn

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >6rsyJ (J:)
mdtgvsqdprhkitkrgqnvtfrcdpisehnrlywyrqtlgqgpefltyfqneaqleksr
llsdrfsaerpkgsfstleiqrteqgdsamylcasslgfgrdvmrfgpgtrllvledlkn
vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
qpalndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaet
wgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >6rsyJ (J:)
gvsqdprhkitkrgqnvtfrcdpisehnrlywyrqtlgqgpefltyfqneaqleksrlls
drfsaerpkgsfstleiqrteqgdsamylcasslgfgrdvmrfgpgtrllvledlknvfp
pevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpa
lndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaetwgr
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