PDB entry 6rqj

View 6rqj on RCSB PDB site
Description: structure of human complement c5 complexed with tick inhibitors omci, raci1 and cirpt1
Deposited on 2019-05-15, released 2020-01-08
The last revision was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: EM
Resolution: 3.5 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Complement C5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Complement C5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: complement inhibitor
    Species: Rhipicephalus pulchellus [TaxId:72859]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5YD59 (Start-164)
      • engineered mutation (74)
      • engineered mutation (98)
  • Chain 'D':
    Compound: Rhipicephalus appendiculatus RaCI1
    Species: Rhipicephalus pulchellus [TaxId:72859]
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Putative 8.9 kDa family member
    Species: Rhipicephalus pulchellus [TaxId:72859]
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6rqjA (A:)
tlqkkieeiaakykhsvvkkccydgacvnndetceqraarislgprcikafteccvvasq
lranishkdmqlgrlhmktllpvskpeirsyfpeswlwevhlvprrkqlqfalpdslttw
eiqgvgisntgicvadtvkakvfkdvflemnipysvvrgeqiqlkgtvynyrtsgmqfcv
kmsavegictsespvidhqgtksskcvrqkvegssshlvtftvlpleiglhninfsletw
fgkeilvktlrvvpegvkresysgvtldprgiygtisrrkefpyripldlvpkteikril
svkgllvgeilsavlsqeginilthlpkgsaeaelmsvvpvfyvfhyletgnhwnifhsd
pliekqklkkklkegmlsimsyrnadysysvwkggsastwltafalrvlgqvnkyveqnq
nsicnsllwlvenyqldngsfkensqyqpiklqgtlpvearenslyltaftvigirkafd
icplvkidtalikadnfllentlpaqstftlaisayalslgdkthpqfrsivsalkreal
vkgnppiyrfwkdnlqhkdssvpntgtarmvettayalltslnlkdinyvnpvikwlsee
qrygggfystqdtinaieglteysllvkqlrlsmdidvsykhkgalhnykmtdknflgrp
vevllnddlivstgfgsglatvhvttvvhktstseevcsfylkidtqdieashyrgygns
dykrivacasykpsreesssgsshavmdislptgisaneedlkalvegvdqlftdyqikd
ghvilqlnsipssdflcvrfrifelfevgflspatftvyeyhrpdkqctmfystsnikiq
kvcegaackcveadcgqmqeeldltisaetrkqtackpeiayaykvsitsitvenvfvky
katlldiyktgeavaekdseitfikkvtctnaelvkgrqylimgkealqikynfsfryiy
pldsltwieywprdttcsscqaflanldefaediflngc

    Sequence, based on observed residues (ATOM records):
    >6rqjA (A:)
qkkieeiaakykhsvvkkccydgacvnndetceqraarislgprcikafteccvvasqlr
anishkdmqlgrlhmktllpvskpeirsyfpeswlwevhlvprrkqlqfalpdslttwei
qgvgisntgicvadtvkakvfkdvflemnipysvvrgeqiqlkgtvynyrtsgmqfcvkm
savegictsespviksskcvrqkvegssshlvtftvlpleiglhninfsletwfgkeilv
ktlrvvpegvkresysgvtldprgiygtisrrkefpyripldlvpkteikrilsvkgllv
geilsavlsqeginilthlpkgsaeaelmsvvpvfyvfhyletgnhwnifhsdpliekqk
lkkklkegmlsimsyrnadysysvwkggsastwltafalrvlgqvnkyveqnqnsicnsl
lwlvenyqldngsfkensqyqpiklqgtlpvearenslyltaftvigirkafdicplvki
dtalikadnfllentlpaqstftlaisayalslgdkthpqfrsivsalkrealvkgnppi
yrfwkdnlqhkdssvpntgtarmvettayalltslnlkdinyvnpvikwlseeqrygggf
ystqdtinaieglteysllvkqlrlsmdidvsykhkgalhnykmtdknflgrpvevllnd
dlivstgfgsglatvhvttvvhktstseevcsfylkidtqdieakrivacasykpsrees
ssgsshavmdislptgisaneedlkalvegvdqlftdyqikdghvilqlnsipssdflcv
rfrifelfevgflspatftvyeyhrpdkqctmfystsnikiqkvcegaackcveadcgqm
qeeldltisaetrkqtackpeiayaykvsitsitvenvfvkykatlldiyktgeavaekd
seitfikkvtctnaelvkgrqylimgkealqikynfsfryiypldsltwieywprdttcs
scqaflanldefaediflngc

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6rqjB (B:)
qeqtyvisapkifrvgaseniviqvygyteafdatisiksypdkkfsyssghvhlssenk
fqnsailtiqpkqlpggqnpvsyvylevvskhfskskrmpitydngflfihtdkpvytpd
qsvkvrvyslnddlkpakretvltfidpegsevdmveeidhigiisfpdfkipsnprygm
wtikakykedfsttgtayfevkeyvlphfsvsiepeynfigyknfknfeitikaryfynk
vvteadvyitfgiredlkddqkemmqtamqntmlingiaqvtfdsetavkelsyysledl
nnkylyiavtviestggfseeaeipgikyvlspyklnlvatplflkpgipypikvqvkds
ldqlvggvpvtlnaqtidvnqetsdldpsksvtrvddgvasfvlnlpsgvtvlefnvktd
apdlpeenqaregyraiaysslsqsylyidwtdnhkallvgehlniivtpkspyidkith
ynylilskgkiihfgtrekfsdasyqsinipvtqnmvpssrllvyyivtgeqtaelvsds
vwlnieekcgnqlqvhlspdadayspgqtvslnmatgmdswvalaavdsavygvqrgakk
plervfqfleksdlgcgaggglnnanvfhlagltfltnanaddsqendepckeil

    Sequence, based on observed residues (ATOM records):
    >6rqjB (B:)
eqtyvisapkifrvgaseniviqvygyteafdatisiksypdkkfsyssghvhlssenkf
qnsailtiqpkqlpggqnpvsyvylevvskhfskskrmpitydngflfihtdkpvytpdq
svkvrvyslnddlkpakretvltfidpegsevdmveeidhigiisfpdfkipsnprygmw
tikakykedfsttgtayfevkeyvlphfsvsiepeynfigyknfknfeitikaryfynkv
vteadvyitfgiredlkddqkemmqtamqntmlingiaqvtfdsetavkelsyysledln
nkylyiavtviestggfseeaeipgikyvlspyklnlvatplflkpgipypikvqvkdsl
dqlvggvpvtlnaqtidvnqetsdldpsksvtrvddgvasfvlnlpsgvtvlefnvktda
pdlpeenqaregyraiaysslsqsylyidwtdnhkallvgehlniivtpkspyidkithy
nylilskgkiihfgtrekfsdasyqsinipvtqnmvpssrllvyyivtgeqtaelvsdsv
wlnieekcgnqlqvhlspdadayspgqtvslnmatgmdswvalaavdsavyglervfqfl
eksdlgcgaggglnnanvfhlagltfltnanaddsqendepck

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6rqjC (C:)
mashhhhhhhhhhsgdsesdctgsepvdafqafsegkeayvlvrstdpkardclkgepag
ekqdntlpvmmtfkqgtdwastdwtftldgakvtatlgqltqnrevvydsqshhchvdkv
ekevpdyemwmldaggleveveccrqkleelasgrnqmyphlkdc

    Sequence, based on observed residues (ATOM records):
    >6rqjC (C:)
sdctgsepvdafqafsegkeayvlvrstdpkardclkgepagekqdntlpvmmtfkqgtd
wastdwtftldgakvtatlgqltqnrevvydsqshhchvdkvekevpdyemwmldaggle
veveccrqkleelasgrnqmyphlkdc

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6rqjD (D:)
gpmeevkttpipnhqcvnatcerkldalgnavitkcpqgclcvvrgasnivpangtcfql
attkppmapgdnkdnkeeesn

    Sequence, based on observed residues (ATOM records):
    >6rqjD (D:)
cvnatcerkldalgnavitkcpqgclcvvrgasnivpangtcfqla

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6rqjE (E:)
khhhhhhsaglevlfqgpmgdvqerghtyvtknvtvedgacvylrnvipngetkalnnpc
vlstcyaadrkvnstlcpnigvdegchvewtpdgvypnccpkhvcpsatass

    Sequence, based on observed residues (ATOM records):
    >6rqjE (E:)
rghtyvtknvtvedgacvylrnvipngetkalnnpcvlstcyaadrkvnstlcpnigvde
gchvewtpdgvypnccpkhvcp