PDB entry 6rps

View 6rps on RCSB PDB site
Description: X-ray crystal structure of carbonic anhydrase XII complexed with a theranostic monoclonal antibody fragment
Class: lyase
Keywords: Anticancer drugs, Carbonic Anhydrase XII, complex, monoclonal antibody, Lyase
Deposited on 2019-05-14, released 2019-11-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.79 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CA12
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43570 (1-261)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d6rpsa1, d6rpsa2
  • Chain 'B':
    Compound: Carbonic anhydrase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CA12
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43570 (1-261)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d6rpsb1, d6rpsb2
  • Chain 'H':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RPS (0-End)
    Domains in SCOPe 2.08: d6rpsh_
  • Chain 'L':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RPS
    Domains in SCOPe 2.08: d6rpsl1, d6rpsl2
  • Chain 'M':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RPS
    Domains in SCOPe 2.08: d6rpsm1, d6rpsm2
  • Chain 'N':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RPS (0-End)
    Domains in SCOPe 2.08: d6rpsn_
  • Heterogens: ZN, ACT, SO4, CD, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6rpsA (A:)
mkwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfll
tnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivhy
nsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfniee
llpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspre
minnfrqvqkfderlvytsfsqggggsggggsggggshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6rpsA (A:)
mkwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfll
tnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivhy
nsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfniee
llpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspre
minnfrqvqkfderlvytsfsq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6rpsB (B:)
mkwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfll
tnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivhy
nsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfniee
llpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspre
minnfrqvqkfderlvytsfsqggggsggggsggggshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6rpsB (B:)
mkwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfll
tnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivhy
nsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfniee
llpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspre
minnfrqvqkfderlvytsfsq

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6rpsH (H:)
qvqlkesgpglvqpsetlsltctvsgfslttysvswvrqpsgkgpewmgrmwydgdtvyn
salksrlsisrdtsknqvflkmnsletdetgtyyctrdfgyfdgsspfdywgqgvmvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdktht

    Sequence, based on observed residues (ATOM records): (download) 
    >6rpsH (H:)
qvqlkesgpglvqpsetlsltctvsgfslttysvswvrqpsgkgpewmgrmwydgdtvyn
salksrlsisrdtsknqvflkmnsletdetgtyyctrdfgyfdgsspfdywgqgvmvtvs
sastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6rpsL (L:)
pvdivltqspatlsvtpgesvslscrasqgistsihwyqqksnesprllikfasqsisgi
psrfsgsgsgtdftlsinrvesedfsvyfcqqtyslpytfgagtklelkrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6rpsL (L:)
vdivltqspatlsvtpgesvslscrasqgistsihwyqqksnesprllikfasqsisgip
srfsgsgsgtdftlsinrvesedfsvyfcqqtyslpytfgagtklelkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >6rpsM (M:)
pvdivltqspatlsvtpgesvslscrasqgistsihwyqqksnesprllikfasqsisgi
psrfsgsgsgtdftlsinrvesedfsvyfcqqtyslpytfgagtklelkrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6rpsM (M:)
vdivltqspatlsvtpgesvslscrasqgistsihwyqqksnesprllikfasqsisgip
srfsgsgsgtdftlsinrvesedfsvyfcqqtyslpytfgagtklelkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >6rpsN (N:)
qvqlkesgpglvqpsetlsltctvsgfslttysvswvrqpsgkgpewmgrmwydgdtvyn
salksrlsisrdtsknqvflkmnsletdetgtyyctrdfgyfdgsspfdywgqgvmvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdktht

    Sequence, based on observed residues (ATOM records): (download) 
    >6rpsN (N:)
qvqlkesgpglvqpsetlsltctvsgfslttysvswvrqpsgkgpewmgrmwydgdtvyn
salksrlsisrdtsknqvflkmnsletdetgtyyctrdfgyfdgsspfdywgqgvmvtvs
sastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks