PDB entry 6rpj

View 6rpj on RCSB PDB site
Description: a non-blocking anti-ctla-4 nanobody complexed with ctla-4
Deposited on 2019-05-14, released 2020-07-08
The last revision was dated 2020-11-11, with a file datestamp of 2020-11-06.
Experiment type: XRAY
Resolution: 3.25 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cytotoxic t-lymphocyte protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CTLA4, CD152
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: A non-blocking CTLA-4 nanobody
    Species: Camelus bactrianus [TaxId:9837]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RPJ (0-End)
  • Chain 'C':
    Compound: cytotoxic t-lymphocyte protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CTLA4, CD152
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: A non-blocking CTLA-4 nanobody
    Species: Camelus bactrianus [TaxId:9837]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RPJ (0-End)
  • Chain 'E':
    Compound: cytotoxic t-lymphocyte protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CTLA4, CD152
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: A non-blocking CTLA-4 nanobody
    Species: Camelus bactrianus [TaxId:9837]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RPJ (0-End)
  • Chain 'G':
    Compound: cytotoxic t-lymphocyte protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CTLA4, CD152
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: A non-blocking CTLA-4 nanobody
    Species: Camelus bactrianus [TaxId:9837]
    Database cross-references and differences (RAF-indexed):
    • PDB 6RPJ (0-End)
  • Heterogens: NAG, NA, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6rpjA (A:)
amhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgnelt
flddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvidpep
ggshhhhhh

    Sequence, based on observed residues (ATOM records):
    >6rpjA (A:)
mhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgneltf
lddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvidpe

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6rpjB (B:)
qvqlqesgggsvqaggsltlscaasgyansntcmgwfrqapgkerervaaisgvgtgtyy
adsvkgrftisrdngkntlflqmnslkpedtamyycaaapegrawcsrdpsgynywgqgt
qvtvssgsmdpggshhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6rpjB (B:)
qvqlqesgggsvqaggsltlscaasgyansntcmgwfrqapgkerervaaisgvgtgtyy
adsvkgrftisrdngkntlflqmnslkpedtamyycaaapegrawcsrdpsgynywgqgt
qvtvs

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6rpjC (C:)
amhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgnelt
flddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvidpep
ggshhhhhh

    Sequence, based on observed residues (ATOM records):
    >6rpjC (C:)
mhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgneltf
lddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvidpe

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6rpjD (D:)
qvqlqesgggsvqaggsltlscaasgyansntcmgwfrqapgkerervaaisgvgtgtyy
adsvkgrftisrdngkntlflqmnslkpedtamyycaaapegrawcsrdpsgynywgqgt
qvtvssgsmdpggshhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6rpjD (D:)
qvqlqesgggsvqaggsltlscaasgyansntcmgwfrqapgkerervaaisgvgtgtyy
adsvkgrftisrdngkntlflqmnslkpedtamyycaaapegrawcsrdpsgynywgqgt
qvtvs

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6rpjE (E:)
amhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgnelt
flddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvidpep
ggshhhhhh

    Sequence, based on observed residues (ATOM records):
    >6rpjE (E:)
mhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgneltf
lddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvidpep

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6rpjF (F:)
qvqlqesgggsvqaggsltlscaasgyansntcmgwfrqapgkerervaaisgvgtgtyy
adsvkgrftisrdngkntlflqmnslkpedtamyycaaapegrawcsrdpsgynywgqgt
qvtvssgsmdpggshhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6rpjF (F:)
qvqlqesgggsvqaggsltlscaasgyansntcmgwfrqapgkerervaaisgvgtgtyy
adsvkgrftisrdngkntlflqmnslkpedtamyycaaapegrawcsrdpsgynywgqgt
qvtvs

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6rpjG (G:)
amhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgnelt
flddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvidpep
ggshhhhhh

    Sequence, based on observed residues (ATOM records):
    >6rpjG (G:)
mhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgneltf
lddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvidpe

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6rpjH (H:)
qvqlqesgggsvqaggsltlscaasgyansntcmgwfrqapgkerervaaisgvgtgtyy
adsvkgrftisrdngkntlflqmnslkpedtamyycaaapegrawcsrdpsgynywgqgt
qvtvssgsmdpggshhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6rpjH (H:)
qvqlqesgggsvqaggsltlscaasgyansntcmgwfrqapgkerervaaisgvgtgtyy
adsvkgrftisrdngkntlflqmnslkpedtamyycaaapegrawcsrdpsgynywgqgt
qvtvs