PDB entry 6rln

View 6rln on RCSB PDB site
Description: Crystal structure of RIP1 kinase in complex with GSK3145095
Class: transferase
Keywords: Inhibitor, Complex, TRANSFERASE
Deposited on 2019-05-02, released 2019-07-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-03, with a file datestamp of 2019-06-28.
Experiment type: XRAY
Resolution: 2.87 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK1, RIP, RIP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13546 (Start-302)
      • engineered mutation (42)
      • engineered mutation (135)
      • engineered mutation (241)
      • engineered mutation (248)
    Domains in SCOPe 2.08: d6rlna_
  • Chain 'B':
    Compound: Receptor-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK1, RIP, RIP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13546 (Start-302)
      • engineered mutation (42)
      • engineered mutation (135)
      • engineered mutation (241)
      • engineered mutation (248)
    Domains in SCOPe 2.08: d6rlnb_
  • Heterogens: K8K, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6rlnA (A:)
mdykddddkmqpdmslnvikmkssdflesaeldsggfgkvslafhrtqglmimktvykgp
nciehnealleeakmmnrlrhsrvvkllgviieegkyslvmeymekgnlmhvlkaemstp
lsvkgriileiiegmaylhgkgvihkdlkpenilvdndfhikiadlglasfkmwsklnne
ehnelrevdgtakknggtlyymapehlndvnakpteksdvysfavvlwaifankepyena
iaeqqlimaiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrpfyls
qle

    Sequence, based on observed residues (ATOM records): (download) 
    >6rlnA (A:)
nvikmkssdflekvslafhrtqglmimktvykgpnciehnealleeakmmnrlrhsrvvk
llgviieegkyslvmeymekgnlmhvlkaemstplsvkgriileiiegmaylhgkgvihk
dlkpenilvdndfhikiadlglasfkmwsklnneehnelgtlyymapehlndvnakptek
sdvysfavvlwaifankepyenaiaeqqlimaiksgnrpdvdditeycpreiislmklcw
eanpearptfpgieekfrpfylsqle

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6rlnB (B:)
mdykddddkmqpdmslnvikmkssdflesaeldsggfgkvslafhrtqglmimktvykgp
nciehnealleeakmmnrlrhsrvvkllgviieegkyslvmeymekgnlmhvlkaemstp
lsvkgriileiiegmaylhgkgvihkdlkpenilvdndfhikiadlglasfkmwsklnne
ehnelrevdgtakknggtlyymapehlndvnakpteksdvysfavvlwaifankepyena
iaeqqlimaiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrpfyls
qle

    Sequence, based on observed residues (ATOM records): (download) 
    >6rlnB (B:)
lnvikmkssdflkvslafhrtqglmimktvykgpnciehnealleeakmmnrlrhsrvvk
llgviieegkyslvmeymekgnlmhvlkaemstplsvkgriileiiegmaylhgkgvihk
dlkpenilvdndfhikiadlglasfkmwsklnneehneltlyymapehlndvnakpteks
dvysfavvlwaifankepyenaiaeqqlimaiksgnrpdvdditeycpreiislmklcwe
anpearptfpgieekfrpfylsqle