PDB entry 6r7h

View 6r7h on RCSB PDB site
Description: structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome
Deposited on 2019-03-28, released 2019-08-28
The last revision was dated 2019-09-04, with a file datestamp of 2019-08-30.
Experiment type: EM
Resolution: 8.8 Å
R-factor: N/A
AEROSPACI score: -0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: COP9 signalosome complex subunit 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GPS1, COPS1, CSN1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: cop9 signalosome complex subunit 2
    Species: Homo sapiens [TaxId:9606]
    Gene: COPS2, CSN2, TRIP15
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: cop9 signalosome complex subunit 3
    Species: Homo sapiens [TaxId:9606]
    Gene: COPS3, CSN3
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: cop9 signalosome complex subunit 4
    Species: Homo sapiens [TaxId:9606]
    Gene: COPS4, CSN4
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: COP9 signalosome complex subunit 5
    Species: Homo sapiens [TaxId:9606]
    Gene: COPS5, CSN5, JAB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: COP9 signalosome complex subunit 6
    Species: Homo sapiens [TaxId:9606]
    Gene: COPS6, CSN6, HVIP
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: COP9 signalosome complex subunit 7b
    Species: Homo sapiens [TaxId:9606]
    Gene: COPS7B, CSN7B
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: cop9 signalosome complex subunit 8
    Species: Homo sapiens [TaxId:9606]
    Gene: COPS8, CSN8
    Database cross-references and differences (RAF-indexed):
  • Chain 'O':
    Compound: Cullin-2
    Species: Homo sapiens [TaxId:9606]
    Gene: CUL2
    Database cross-references and differences (RAF-indexed):
  • Chain 'P':
    Compound: Elongin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOB, TCEB2
    Database cross-references and differences (RAF-indexed):
  • Chain 'Q':
    Compound: Elongin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOC, TCEB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: E3 ubiquitin-protein ligase RBX1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6R7H (0-89)

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records:
    >6r7hA (A:)
    venpsldleqyaasysglmrierlqfiadhcptlrvealkmalsfvqrtfnvdmyeeihr
    klseatrsslrelqnapdaipesgveppaldtawveatrkkallklekldtdlknykgns
    ikesirrghddlgdhyldcgdlsnalkcysrardyctsakhvinmclnvikvsvylqnws
    hvlsyvskaestpeiaeqrgerdsqtqailtklkcaaglaelaarkykqaakclllasfd
    hcdfpellspsnvaiygglcalatfdrqelqrnvissssfklflelepqvrdiifkfyes
    kyasclkmldemkdnllldmylaphvrtlytqirnraliqyfspyvsadmhrmaaafntt
    vaaledeltqlileglisarvdshskilyardvdqrsttfeksllmgkefqrrakammlr
    aavlrnqihvksp
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >6r7hB (B:)
    vdlenqyynskalkeddpkaalssfqkvlelegekgewgfkalkqmikinfkltnfpemm
    nrykqlltyirsavtrnyseksinsildyistskqmdllqefyettlealkdakndrlwf
    ktntklgklylereeygklqkilrqlhqscqtddgeddlkkgtqlleiyaleiqmytaqk
    nnkklkalyeqslhiksaiphplimgvirecggkmhlregefekahtdffeafknydesg
    sprrttclkylvlanmlmksginpfdsqeakpykndpeilamtnlvsayqnnditefeki
    lktnhsnimddpfirehieellrnirtqvliklikpytrihipfiskelnidvadvesll
    vqcildntihgridqvnqlleldhqkrggarytaldkwtnqlnslnqavvskla
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6r7hC (C:)
    masaleqfvnsvrqlsaqgqmtqlcelinksgellaknlshldtvlgaldvqehslgvla
    vlfvkfsmpsvpdfetlfsqvqlfistcngehiryatdtfaglchqltnalverkqplrg
    igilkqaidkmqmntnqltsihadlcqlcllakcfkpalpyldvdmmdickengaydakh
    flcyyyyggmiytglknferalyfyeqaittpamavshimlesykkyilvslillgkvqq
    lpkytsqivgrfikplsnayhelaqvystnnpselrnlvnkhsetftrdnnmglvkqcls
    slykkniqrltktfltlslqdmasrvqlsgpqeaekyvlhmiedgeifasinqkdgmvsf
    hdnpekynnpamlhnidqemlkcielderlkamdqeitvnpqf
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >6r7hD (D:)
    maaavrqdlaqlmnssgshkdlagkyrqilekaiqlsgaeqlealkafveamvnenvslv
    isrqlltdfcthlpnlpdstakeiyhftlekiqprvisfeeqvasirqhlasiyekeedw
    rnaaqvlvgipletgqkqynvdykletylkiarlyledddpvqaeayinrasllqnestn
    eqlqihykvcyarvldyrrkfieaaqrynelsyktivheserlealkhalhctilasagq
    qrsrmlatlfkdercqqlaaygilekmyldriirgnqlqefaamlmphqkattadgssil
    draviehnllsasklynnitfeelgalleipaakaekiasqmitegrmngfidqidgivh
    fetrealptwdkqiqslcfqvnnllekisqtapewtaqameaqmaq
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records:
    >6r7hE (E:)
    sideiykydkkqqqeilaakpwtkdhhyfkyckisalallkmvmharsggnlevmglmlg
    kvdgetmiimdsfalpvegtetrvnaqaaayeymaayienakqvgrlenaigwyhshpgy
    gcwlsgidvstqmlnqqfqepfvavvidptrtisagkvnlgafrtypkgykppdegpsey
    qtiplnkiedfgvhckqyyalevsyfkssldrkllellwnkywvntlsssslltnadytt
    gqvfdlsekleqseaqlgrgsfmlglethdrksedklakatrdsckttieaihglmsqvi
    kdklfnqinis
    

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >6r7hF (F:)
    svmacgvtgsvsvalhplvilnisdhwirmrsqegrpvqvigaligkqegrnievmnsfe
    llshtveekiiidkeyyytkeeqfkqvfkeleflgwyttggppdpsdihvhkqvceiies
    plflklnpmtkhtdlpvsvfesvidiingeatmlfaeltytlateeaerigvdhvarmta
    tgsgenstvaehliaqhsaikmlhsrvklileyvkaseagevpfnheilreayalchclp
    vlstdkfktdfydqcndvglmaylgtitktcntmnqfvnkfnvlydrq
    

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records:
    >6r7hG (G:)
    ssnlleqfillakgtsgsaltalisqvleapgvyvfgellelanvqelaeganaaylqll
    nlfaygtypdyiankeslpelstaqqnklkhltivslasrmkcipysvllkdlemrnlre
    ledliieavytdiiqgkldqrnqllevdfcigrdirkkdinnivktlhewcdgceavllg
    ieqqvlranqykenhnrtqqqveaevtn
    

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6r7hH (H:)
    fsfkklldqcenqeleapggiatppvygqllalyllhndmnnarylwkrippaiksanse
    lggiwsvgqriwqrdfpgiyttinahqwsetvqpimealrdatrrrafalvsqaytsiia
    ddfaafvglpveeavkgileqgwqadsttrmvlprkpvagaldvsfnkfiplsepapvpp
    ipneqqlarltdyvaflen
    

    Sequence, based on observed residues (ATOM records):
    >6r7hH (H:)
    fsfkklldqcenqeleapggiatppvygqllalyllhndmnnarylwkrippaiksanse
    lggiwsvgqriwqrdfpgiyttinahqwsetvqpimealrdatrrrafalvsqaytsiia
    ddfaafvglpveeavkgileqgwqadsttrmvlprqlarltdyvaflen
    

  • Chain 'O':
    Sequence; same for both SEQRES and ATOM records:
    >6r7hO (O:)
    mslkprvvdfdetwnkllttikavvmleyveratwndrfsdiyalcvaypeplgerlyte
    tkiflenhvrhlhkrvleseeqvlvmyhryweeyskgadymdclyrylntqfikknklte
    adlqygyggvdmneplmeigelaldmwrklmveplqailirmllreikndrggedpnqkv
    ihgvinsfvhveqykkkfplkfyqeifespfltetgeyykqeasnllqesncsqymekvl
    grlkdeeircrkylhpssytkvihecqqrmvadhlqflhaechniirqekkndmanmyvl
    lravstglphmiqelqnhihdeglratsnltqenmptlfvesvlevhgkfvqlintvlng
    dqhfmsaldkaltsvvnyrepksvckapellakycdnllkksakgmtenevedrltsfit
    vfkyiddkdvfqkfyarmlakrlihglsmsmdseeaminklkqacgyeftsklhrmytdm
    svsadlnnkfnnfiknqdtvidlgisfqiyvlqagawpltqapsstfaipqeleksvqmf
    elfysqhfsgrkltwlhylctgevkmnylgkpyvamvttyqmavllafnnsetvsykelq
    dstqmnekeltktikslldvkminhdsekedidaessfslnmnfsskrtkfkit
    

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records:
    >6r7hP (P:)
    mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
    gftsqtarpqapatvglafraddtfealciepfssppelpdvmk
    

  • Chain 'Q':
    Sequence; same for both SEQRES and ATOM records:
    >6r7hQ (Q:)
    mdgeektyggcegpdamyvklissdghefivkrehaltsgtikamlsgpgqfaenetnev
    nfreipshvlskvcmyftykvrytnssteipefpiapeialellmaanfldc
    

  • Chain 'R':
    Sequence; same for both SEQRES and ATOM records:
    >6r7hR (R:)
    kkrfevkkwnavalwawdivvdncaicrnhimdlciecqanqasatseectvawgvcnha
    fhfhcisrwlktrqvcpldnrewefqkygh