PDB entry 6r6i

View 6r6i on RCSB PDB site
Description: Crystal structure of transthyretin mutant A25T in complex with CHF5074, a flurbiprofen analogue
Class: transport protein
Keywords: Amyloidosis, tetramer, binding protein, TRANSPORT PROTEIN
Deposited on 2019-03-27, released 2019-09-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-09-11, with a file datestamp of 2019-09-06.
Experiment type: XRAY
Resolution: 1.47 Å
R-factor: N/A
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: TTR, PALB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766
      • engineered mutation (44)
    Domains in SCOPe 2.07: d6r6ia_
  • Chain 'B':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: TTR, PALB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766
      • engineered mutation (44)
    Domains in SCOPe 2.07: d6r6ib_
  • Heterogens: H50, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6r6iA (A:)
mashrllllclaglvfvseagptgtgeskcplmvkvldavrgsptinvavhvfrkaaddt
wepfasgktsesgelhgltteeefvegiykveidtksywkalgispfhehaevvftands
gprrytiaallspysysttavvtnpke

    Sequence, based on observed residues (ATOM records): (download) 
    >6r6iA (A:)
cplmvkvldavrgsptinvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtnp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6r6iB (B:)
mashrllllclaglvfvseagptgtgeskcplmvkvldavrgsptinvavhvfrkaaddt
wepfasgktsesgelhgltteeefvegiykveidtksywkalgispfhehaevvftands
gprrytiaallspysysttavvtnpke

    Sequence, based on observed residues (ATOM records): (download) 
    >6r6iB (B:)
cplmvkvldavrgsptinvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtn