PDB entry 6r5f

View 6r5f on RCSB PDB site
Description: crystal structure of rip1 kinase in complex with dhp77
Deposited on 2019-03-25, released 2019-05-01
The last revision was dated 2019-08-21, with a file datestamp of 2019-08-16.
Experiment type: XRAY
Resolution: 3.25 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK1, RIP, RIP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13546 (Start-302)
      • engineered mutation (42)
      • engineered mutation (135)
      • engineered mutation (241)
      • engineered mutation (248)
  • Chain 'B':
    Compound: Receptor-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK1, RIP, RIP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13546 (Start-302)
      • engineered mutation (42)
      • engineered mutation (135)
      • engineered mutation (241)
      • engineered mutation (248)
  • Chain 'C':
    Compound: Receptor-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK1, RIP, RIP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13546 (Start-302)
      • engineered mutation (42)
      • engineered mutation (135)
      • engineered mutation (241)
      • engineered mutation (248)
  • Chain 'D':
    Compound: Receptor-interacting serine/threonine-protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK1, RIP, RIP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13546 (Start-302)
      • engineered mutation (42)
      • engineered mutation (135)
      • engineered mutation (241)
      • engineered mutation (248)
  • Heterogens: JSW

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6r5fA (A:)
mdykddddkmqpdmslnvikmkssdflesaeldsggfgkvslafhrtqglmimktvykgp
nciehnealleeakmmnrlrhsrvvkllgviieegkyslvmeymekgnlmhvlkaemstp
lsvkgriileiiegmaylhgkgvihkdlkpenilvdndfhikiadlglasfkmwsklnne
ehnelrevdgtakknggtlyymapehlndvnakpteksdvysfavvlwaifankepyena
iaeqqlimaiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrpfyls
qle

    Sequence, based on observed residues (ATOM records):
    >6r5fA (A:)
vikmkssdslafhrtqglmimktgpnciehnealleeakmmnrlrhsrvvkllgviieeg
kyslvmeymekgnlmhvlkaemstplsvkgriileiiegmaylhgkgvihkdlkpenilv
dndfhikiadlglasfkmwsklnneetlyymapehlndvnakpteksdvysfavvlwaif
ankepyenaiaeqqlimaiksgnrpdvdditeycpreiislmklcweanpearptfpgie
ekfrpfylsqle

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6r5fB (B:)
mdykddddkmqpdmslnvikmkssdflesaeldsggfgkvslafhrtqglmimktvykgp
nciehnealleeakmmnrlrhsrvvkllgviieegkyslvmeymekgnlmhvlkaemstp
lsvkgriileiiegmaylhgkgvihkdlkpenilvdndfhikiadlglasfkmwsklnne
ehnelrevdgtakknggtlyymapehlndvnakpteksdvysfavvlwaifankepyena
iaeqqlimaiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrpfyls
qle

    Sequence, based on observed residues (ATOM records):
    >6r5fB (B:)
ikmkssdflvslafhrtqglmimktvykgpnciehnealleeakmmnrlrhsrvvkllgv
iieegkyslvmeymekgnlmhvlkaemstplsvkgriileiiegmaylhgkgvihkdlkp
enilvdndfhikiadlglasfkmwsklnngtlyymapehlndvnakpteksdvysfavvl
waifankepyenaiaeqqlimaiksgnrpdvdditeycpreiislmklcweanpearptf
pgieekfrpfylsqle

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6r5fC (C:)
mdykddddkmqpdmslnvikmkssdflesaeldsggfgkvslafhrtqglmimktvykgp
nciehnealleeakmmnrlrhsrvvkllgviieegkyslvmeymekgnlmhvlkaemstp
lsvkgriileiiegmaylhgkgvihkdlkpenilvdndfhikiadlglasfkmwsklnne
ehnelrevdgtakknggtlyymapehlndvnakpteksdvysfavvlwaifankepyena
iaeqqlimaiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrpfyls
qle

    Sequence, based on observed residues (ATOM records):
    >6r5fC (C:)
vikmkssdflkvslafhrtqglmimktvykhnealleeakmmnrlrhsrvvkllgviiee
gkyslvmeymekgnlmhvlkaemstplsvkgriileiiegmaylhgkgvihkdlkpenil
vdndfhikiadlglasfkmwsklnnegtlyymapehlndvnakpteksdvysfavvlwai
fankepyenaiaeqqlimaiksgnrpdvdditeycpreiislmklcweanpearptfpgi
eekfrpfylsqle

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6r5fD (D:)
mdykddddkmqpdmslnvikmkssdflesaeldsggfgkvslafhrtqglmimktvykgp
nciehnealleeakmmnrlrhsrvvkllgviieegkyslvmeymekgnlmhvlkaemstp
lsvkgriileiiegmaylhgkgvihkdlkpenilvdndfhikiadlglasfkmwsklnne
ehnelrevdgtakknggtlyymapehlndvnakpteksdvysfavvlwaifankepyena
iaeqqlimaiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrpfyls
qle

    Sequence, based on observed residues (ATOM records):
    >6r5fD (D:)
kmkssdflvslafhrtqglmimktvciehnealleeakmmnrlrhsrvvkllgviieegk
yslvmeymekgnlmhvlkaemstplsvkgriileiiegmaylhgkgvihkdlkpenilvd
ndfhikiadlglasfkmwsklnngtlyymapehlndvnakpteksdvysfavvlwaifan
kepyenaiaeqqlimaiksgnrpdvdditeycpreiislmklcweanpearptfpgieek
frpfylsqle