PDB entry 6r4v

View 6r4v on RCSB PDB site
Description: Crystal structure of human geranylgeranyl diphosphate synthase bound to ibandronate
Class: transferase
Keywords: Bisphosphonate, ibandronate, geranylgeranyl diphosphate, prenyltransferase, TRANSFERASE
Deposited on 2019-03-24, released 2019-09-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-09, with a file datestamp of 2019-10-04.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • variant (115)
    Domains in SCOPe 2.08: d6r4va_
  • Chain 'B':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • variant (115)
    Domains in SCOPe 2.08: d6r4vb_
  • Chain 'C':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • variant (115)
    Domains in SCOPe 2.08: d6r4vc_
  • Chain 'D':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • variant (115)
    Domains in SCOPe 2.08: d6r4vd_
  • Chain 'E':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • variant (115)
    Domains in SCOPe 2.08: d6r4ve_
  • Chain 'F':
    Compound: Geranylgeranyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749
      • variant (115)
    Domains in SCOPe 2.08: d6r4vf_
  • Heterogens: BFQ, MG, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6r4vA (A:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6r4vA (A:)
qetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllid
diednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelhq
gqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglff
qirddyanlhsenksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycv
hyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6r4vB (B:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6r4vB (B:)
tqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnaslli
ddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelh
qgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglf
fqirddyanlhsnksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycv
hyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfkee

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6r4vC (C:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6r4vC (C:)
ktqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasll
iddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllel
hqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlgl
ffqirddyanlhssenksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikk
ycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfkeen

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6r4vD (D:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6r4vD (D:)
qetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllid
diednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelhq
gqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglff
qirddyanlhsksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhy
ledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfke

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6r4vE (E:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6r4vE (E:)
tqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnaslli
ddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelh
qgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglf
fqirddyanlhsnksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycv
hyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6r4vF (F:)
gsgsgsgmektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievt
emlhnaslliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavk
lftrqllelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedl
kpllntlglffqirddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqni
lrqrtenidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlsk
mfkeene

    Sequence, based on observed residues (ATOM records): (download) 
    >6r4vF (F:)
qetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllid
diednsklrrgfpvahsiygipsvinsanyvyflglekvltldhqdavklftrqllelhq
gqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglff
qirddyanlhnksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhy
ledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfk