PDB entry 6r0x

View 6r0x on RCSB PDB site
Description: The extracellular domain of G6b-B in complex with Fab fragment and DP12 heparin oligosaccharide.
Class: blood clotting
Keywords: platelets, signaling, ITIM-receptor, G6b-B, heparin, BLOOD CLOTTING
Deposited on 2019-03-13, released 2019-09-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 3.13 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: antibody fab fragment heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6R0X
    Domains in SCOPe 2.08: d6r0xa_
  • Chain 'B':
    Compound: antibody fab fragment light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6R0X (Start-233)
    Domains in SCOPe 2.08: d6r0xb1, d6r0xb2
  • Chain 'C':
    Compound: antibody fab fragment heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6R0X (Start-239)
    Domains in SCOPe 2.08: d6r0xc_
  • Chain 'D':
    Compound: antibody fab fragment light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6R0X (Start-233)
    Domains in SCOPe 2.08: d6r0xd1, d6r0xd2
  • Chain 'E':
    Compound: Megakaryocyte and platelet inhibitory receptor G6b
    Species: Homo sapiens [TaxId:9606]
    Gene: MPIG6B, C6orf25, G6B, G6B-B
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95866
      • engineered mutation (14)
      • engineered mutation (49-51)
      • engineered mutation (53)
  • Chain 'F':
    Compound: Megakaryocyte and platelet inhibitory receptor G6b
    Species: Homo sapiens [TaxId:9606]
    Gene: MPIG6B, C6orf25, G6B, G6B-B
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95866
      • engineered mutation (14)
      • engineered mutation (49-51)
      • engineered mutation (53)

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6r0xA (A:)
mkcswvifflmavvtgvnsevqlqqsgaelvkpgasvklsctasgfniketyihwvkqrp
eqglewigridpadvygrydpkfqgkatitadtssnsaylqvssltsedtavyycarsyg
ssygidywgqgtsvtvssakttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwn
sgslssgvhtfpavlqsdlytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdc

    Sequence, based on observed residues (ATOM records): (download) 
    >6r0xA (A:)
evqlqqsgaelvkpgasvklsctasgfniketyihwvkqrpeqglewigridpadvygry
dpkfqgkatitadtssnsaylqvssltsedtavyycarsygssygidywgqgtsvtvssa
kttppsvyplapsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlsssv
tvpsstwpsetvtcnvahpasstkvdkkivpr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6r0xB (B:)
mmssaqflgllllcfqgtrcdiqmtqttsslsaslgdrvtiscrasqdisnylnwyqqkp
dgtvklliyytstlhsgvpsrfsgsgsgtdysltisnleqedvatyfcqqgytlpwtfgg
gtkleikradaaptvsifppsseqltsggasvvcflnnfypkdvnvkwkidgserqsgvl
nswtdqdskdstysmsstltltkdeyerhnsytceathktstspivtsfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >6r0xB (B:)
diqmtqttsslsaslgdrvtiscrasqdisnylnwyqqkpdgtvklliyytstlhsgvps
rfsgsgsgtdysltisnleqedvatyfcqqgytlpwtfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdvnvkwkidgserqsgvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivtsfnrnec

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6r0xC (C:)
mkcswvifflmavvtgvnsevqlqqsgaelvkpgasvklsctasgfniketyihwvkqrp
eqglewigridpadvygrydpkfqgkatitadtssnsaylqvssltsedtavyycarsyg
ssygidywgqgtsvtvssakttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwn
sgslssgvhtfpavlqsdlytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdc

    Sequence, based on observed residues (ATOM records): (download) 
    >6r0xC (C:)
vqlqqsgaelvkpgasvklsctasgfniketyihwvkqrpeqglewigridpadvygryd
pkfqgkatitadtssnsaylqvssltsedtavyycarsygssygidywgqgtsvtvssak
ttppsvyplapsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlsssvt
vpsstwpsetvtcnvahpasstkvdkkivprdc

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6r0xD (D:)
mmssaqflgllllcfqgtrcdiqmtqttsslsaslgdrvtiscrasqdisnylnwyqqkp
dgtvklliyytstlhsgvpsrfsgsgsgtdysltisnleqedvatyfcqqgytlpwtfgg
gtkleikradaaptvsifppsseqltsggasvvcflnnfypkdvnvkwkidgserqsgvl
nswtdqdskdstysmsstltltkdeyerhnsytceathktstspivtsfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >6r0xD (D:)
diqmtqttsslsaslgdrvtiscrasqdisnylnwyqqkpdgtvklliyytstlhsgvps
rfsgsgsgtdysltisnleqedvatyfcqqgytlpwtfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdvnvkwkidgserqsgvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathkspivtsfnrnec

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.