PDB entry 6qxh

View 6qxh on RCSB PDB site
Description: Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with dUMP
Class: transferase
Keywords: human thymidylate synthase, folate pathway, substrate, dUMP, TRANSFERASE
Deposited on 2019-03-07, released 2019-04-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-10, with a file datestamp of 2019-07-05.
Experiment type: XRAY
Resolution: 2.04 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6qxha_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6qxhb_
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6qxhc_
  • Heterogens: UMP, PEG, CL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6qxhA (A:)
mrgshhhhhhgsmpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkd
drtgtgtlsvfgmqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvki
wdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidti
ktnpddrriimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfnia
syalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkveki
ddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >6qxhA (A:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmema

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6qxhB (B:)
mrgshhhhhhgsmpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkd
drtgtgtlsvfgmqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvki
wdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidti
ktnpddrriimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfnia
syalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkveki
ddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >6qxhB (B:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmema

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6qxhC (C:)
mrgshhhhhhgsmpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkd
drtgtgtlsvfgmqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvki
wdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidti
ktnpddrriimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfnia
syalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkveki
ddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >6qxhC (C:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav