PDB entry 6qvo

View 6qvo on RCSB PDB site
Description: Crystal structure of human MTH1 in complex with N6-methyl-dAMP
Class: hydrolase
Keywords: ----, hydrolase
Deposited on 2019-03-04, released 2020-03-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-03-18, with a file datestamp of 2020-03-13.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 7,8-dihydro-8-oxoguanine triphosphatase
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT1, MTH1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6qvoa_
  • Chain 'B':
    Compound: 7,8-dihydro-8-oxoguanine triphosphatase
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT1, MTH1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6qvob_
  • Chain 'C':
    Compound: 7,8-dihydro-8-oxoguanine triphosphatase
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT1, MTH1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6qvoc_
  • Chain 'D':
    Compound: 7,8-dihydro-8-oxoguanine triphosphatase
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT1, MTH1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6qvod_
  • Heterogens: 6MA, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6qvoA (A:)
mywsnqitrrlgervqgfmsgispqqmgepegswsgknpgtmgasrlytlvlvlqpqrvl
lgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvdalhkvgqivfefvgepe
lmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsywfplllqkkkfhgyfkf
qgqdtildytlrevdtv

    Sequence, based on observed residues (ATOM records): (download) 
    >6qvoA (A:)
asrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvd
alhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsy
wfplllqkkkfhgyfkfqgqdtildytlrevdtv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6qvoB (B:)
mywsnqitrrlgervqgfmsgispqqmgepegswsgknpgtmgasrlytlvlvlqpqrvl
lgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvdalhkvgqivfefvgepe
lmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsywfplllqkkkfhgyfkf
qgqdtildytlrevdtv

    Sequence, based on observed residues (ATOM records): (download) 
    >6qvoB (B:)
asrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvd
alhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsy
wfplllqkkkfhgyfkfqgqdtildytlrev

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6qvoC (C:)
mywsnqitrrlgervqgfmsgispqqmgepegswsgknpgtmgasrlytlvlvlqpqrvl
lgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvdalhkvgqivfefvgepe
lmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsywfplllqkkkfhgyfkf
qgqdtildytlrevdtv

    Sequence, based on observed residues (ATOM records): (download) 
    >6qvoC (C:)
gasrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltv
dalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpdds
ywfplllqkkkfhgyfkfqgqdtildytlrevdtv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6qvoD (D:)
mywsnqitrrlgervqgfmsgispqqmgepegswsgknpgtmgasrlytlvlvlqpqrvl
lgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvdalhkvgqivfefvgepe
lmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsywfplllqkkkfhgyfkf
qgqdtildytlrevdtv

    Sequence, based on observed residues (ATOM records): (download) 
    >6qvoD (D:)
asrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvd
alhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsy
wfplllqkkkfhgyfkfqgqdtildytlrevd