PDB entry 6qmd

View 6qmd on RCSB PDB site
Description: Small molecule inhibitor of the KEAP1-NRF2 protein-protein interaction
Class: protein binding
Keywords: Protein ubiquitination, oxidative stress, kelch motif, PROTEIN BINDING
Deposited on 2019-02-07, released 2019-04-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-22, with a file datestamp of 2019-05-17.
Experiment type: XRAY
Resolution: 1.94 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kelch-like ECH-associated protein 1
    Species: Mus musculus [TaxId:10090]
    Gene: Keap1, Inrf2, Kiaa0132
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6qmda_
  • Heterogens: J6N, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6qmdA (A:)
mgsshhhhhhssglvprgpkvgrliytaggyfrqslsyleaynpsngswlrladlqvprs
glagcvvggllyavggrnnspdgntdssaldcynpmtnqwspcasmsvprnrigvgvidg
hiyavggshgcihhssveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtnr
lnsaecyypernewrmitpmntirsgagvcvlhnciyaaggydgqdqlnsverydvetet
wtfvapmrhhrsalgitvhqgkiyvlggydghtfldsvecydpdsdtwsevtrmtsgrsg
vgvavtmepcrkqidqqnctc

    Sequence, based on observed residues (ATOM records): (download) 
    >6qmdA (A:)
grliytaggyfrqslsyleaynpsngswlrladlqvprsglagcvvggllyavggrnnsp
dgntdssaldcynpmtnqwspcasmsvprnrigvgvidghiyavggshgcihhssverye
perdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitpmn
tirsgagvcvlhnciyaaggydgqdqlnsverydvetetwtfvapmrhhrsalgitvhqg
kiyvlggydghtfldsvecydpdsdtwsevtrmtsgrsgvgvavtmepc