PDB entry 6qje

View 6qje on RCSB PDB site
Description: Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole
Class: transferase
Keywords: GALK1, fragment, fragment-bound, galactokinase 1, sugar kinase, TRANSFERASE
Deposited on 2019-01-24, released 2019-02-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (Start-391)
      • engineered mutation (251-252)
    Domains in SCOPe 2.08: d6qjea1, d6qjea2
  • Chain 'B':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (1-391)
      • expression tag (0)
      • engineered mutation (251-252)
    Domains in SCOPe 2.08: d6qjeb1, d6qjeb2, d6qjeb3
  • Chain 'C':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (Start-391)
      • engineered mutation (251-252)
    Domains in SCOPe 2.08: d6qjec1, d6qjec2
  • Chain 'D':
    Compound: Galactokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GALK1, GALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51570 (Start-391)
      • engineered mutation (251-252)
    Domains in SCOPe 2.08: d6qjed1, d6qjed2
  • Heterogens: GAL, HFK, J4Q, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6qjeA (A:)
haalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelm
tvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaa
plpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagm
pcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrr
rqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdy
rafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasa
aphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6qjeA (A:)
alrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtv
lvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaapl
pgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpc
gimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrrrq
ceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyra
fgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaap
hamrhiqehyggtatfylsqaadgakvlcl

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6qjeB (B:)
haalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelm
tvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaa
plpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagm
pcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrr
rqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdy
rafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasa
aphamrhiqehyggtatfylsqaadgakvlcl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6qjeC (C:)
haalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelm
tvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaa
plpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagm
pcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrr
rqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdy
rafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasa
aphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6qjeC (C:)
alrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelmtv
lvgsprlvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaaplpgf
savvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagmpcgim
dqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhsseypvrrrqceevar
algaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdyrafgrlmv
eshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasaaphamrhi
qehyggtatfylsqaadgakvlcl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6qjeD (D:)
haalrqpqvaellaearrafreefgaepelavsapgrvnligehtdynqglvlpmalelm
tvlvgsprkdglvsllttsegadepqrlqfplptaqrslepgtprwanyvkgviqyypaa
plpgfsavvvssvplggglsssaslevatytflqqlcpdsgtiaaraqvcqqaehsfagm
pcgimdqfislmgqkghallidcrsletslvplsdpklavlitnsnvrhslasseypvrr
rqceevaralgaaslrevqleeleaardlvskegfrrarhvvgeirrtaqaaaalrrgdy
rafgrlmveshrslrddyevscpeldqlveaalavpgvygsrmtgggfggctvtlleasa
aphamrhiqehyggtatfylsqaadgakvlcl

    Sequence, based on observed residues (ATOM records): (download) 
    >6qjeD (D:)
qpqvaellaeafreefgepelavsapgrvnligehtdynqglvlpmalelmtvlvgspdg
lvsllttrlqfplppgtprwanyvkgviqyypaaplpgfsavvvssvplggglsssasle
vatytflqqlcpdsqvcqqaehsfmdqfislmgqkghallidcrsletslvplsdpklav
litnsnvrhslasseypvrrrqceevaralgaaslrevqleeleaardlvskegfrrarh
vvgeirrtaqaaaalrrgdyrafgrlmveshrslrddyevscpeldqlveaalavpgvyg
srmtgggfggctvtlleasaaphamrhiqehyggtatfylsqaadgakvlcl