PDB entry 6qip

View 6qip on RCSB PDB site
Description: Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the albumin-biniding side chain of the human growth hormone derivative somapacitan
Class: transport protein
Keywords: complex, albumin binding, long-acting growth hormone, somapacitan, HORMONE, TRANSPORT PROTEIN
Deposited on 2019-01-21, released 2020-02-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-22, with a file datestamp of 2020-04-17.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serum albumin
    Species: Homo sapiens [TaxId:9606]
    Gene: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02768 (Start-584)
      • engineered mutation (417)
      • engineered mutation (419)
      • engineered mutation (504)
      • engineered mutation (546)
    Domains in SCOPe 2.08: d6qipa1, d6qipa2, d6qipa3
  • Chain 'B':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6qipb1, d6qipb2
  • Chain 'C':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (0-98)
      • expression tag (99)
    Domains in SCOPe 2.08: d6qipc1, d6qipc2
  • Heterogens: MES, HDW, CYS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6qipA (A:)
dahksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesae
ncdkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpev
dvmctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllp
kldelrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltk
vhtecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempa
dlpslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekc
caaadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqmsa
ptlvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkcctes
lvnrrpcfsalevdetyvpkefnagtftfhadictlsekerqikkqtalvelvkhkpkat
keqlkaamddfaafvekcckaddketcfaeegkklvaasqaalgl

    Sequence, based on observed residues (ATOM records): (download) 
    >6qipA (A:)
ksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesaencd
kslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpevdvm
ctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllpkld
elrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltkvht
ecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempadlp
slaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekccaa
adphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqmsaptl
vevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkccteslvn
rrpcfsalevdetyvpkefnagtftfhadictlsekerqikkqtalvelvkhkpkatkeq
lkaamddfaafvekcckaddketcfaeegkklvaasqaalgl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6qipB (B:)
aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
tvksgdehhyccivqhaglaqplrvelespakss

    Sequence, based on observed residues (ATOM records): (download) 
    >6qipB (B:)
shlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywe
kettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdl
kqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsm
rlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltv
ksgdehhyccivqhaglaqplrveles

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6qipC (C:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdmhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6qipC (C:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdmh