PDB entry 6qio

View 6qio on RCSB PDB site
Description: Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the human growth hormone derivative somapacitan
Class: hormone
Keywords: complex, albumin binding, long-acting growth hormone, somapacitan, HORMONE
Deposited on 2019-01-21, released 2020-02-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-22, with a file datestamp of 2020-04-17.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serum albumin
    Species: Homo sapiens [TaxId:9606]
    Gene: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02768 (Start-584)
      • engineered mutation (417)
      • engineered mutation (419)
      • engineered mutation (504)
      • engineered mutation (546)
    Domains in SCOPe 2.08: d6qioa1, d6qioa2, d6qioa3
  • Chain 'B':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6qiob1, d6qiob2
  • Chain 'C':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (0-98)
      • expression tag (99)
    Domains in SCOPe 2.08: d6qioc1, d6qioc2
  • Chain 'D':
    Compound: Somatotropin
    Species: Homo sapiens [TaxId:9606]
    Gene: GH1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6qiod_
  • Heterogens: MES, CYS, JG5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6qioA (A:)
dahksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesae
ncdkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpev
dvmctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllp
kldelrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltk
vhtecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempa
dlpslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekc
caaadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqmsa
ptlvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkcctes
lvnrrpcfsalevdetyvpkefnagtftfhadictlsekerqikkqtalvelvkhkpkat
keqlkaamddfaafvekcckaddketcfaeegkklvaasqaalgl

    Sequence, based on observed residues (ATOM records): (download) 
    >6qioA (A:)
hksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesaenc
dkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpevdv
mctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllpkl
delrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltkvh
tecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempadl
pslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekcca
aadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqmsapt
lvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkccteslv
nrrpcfsalevdetyvpkefnagtftfhadictlsekerqikkqtalvelvkhkpkatke
qlkaamddfaafvekcckaddketcfaeegkklvaasqaalgl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6qioB (B:)
aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
tvksgdehhyccivqhaglaqplrvelespakss

    Sequence, based on observed residues (ATOM records): (download) 
    >6qioB (B:)
shlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywe
kettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdl
kqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsm
rlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltv
ksgdehhyccivqhaglaqplrveles

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6qioC (C:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdmhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6qioC (C:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdmh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6qioD (D:)
fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
psnreetqqksnlellrisllliqswlepvqflrsvfanscvygasdsnvydllkdleeg
iqtlmgrledgsprtgqifkqtyskfdtnshnddallknygllycfrkdmdkvetflriv
qcrsvegscgf

    Sequence, based on observed residues (ATOM records): (download) 
    >6qioD (D:)
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