PDB entry 6qhb

View 6qhb on RCSB PDB site
Description: Crystal Structure of Human Kallikrein 6 in complex with GSK578724A
Class: hydrolase
Keywords: Protease, Inhibitor, Complex, HYDROLASE
Deposited on 2019-01-16, released 2019-02-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-02-27, with a file datestamp of 2019-02-22.
Experiment type: XRAY
Resolution: 1.84 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kallikrein-6
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK6, PRSS18, PRSS9
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92876 (0-222)
      • engineered mutation (56)
      • engineered mutation (58)
      • engineered mutation (112)
    Domains in SCOPe 2.08: d6qhba_
  • Chain 'B':
    Compound: Kallikrein-6
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK6, PRSS18, PRSS9
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92876 (0-End)
      • engineered mutation (56)
      • engineered mutation (58)
      • engineered mutation (112)
    Domains in SCOPe 2.08: d6qhbb_
  • Heterogens: J2W, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6qhbA (A:)
lvhggpcdktshpyqaalytsghllcggvlihplwvltaahckkpnlqvflgkhnlgqqe
ssqeqssvvravihpdydaashdqdimllrlarpaklseliqplplerdcsaqttschil
gwgktadgdfpdtiqcayihlvsreecehaypgqitqnmlcagdekygkdscqgdsggpl
vcgdhlrglvswgnipcgskekpgvytnvcrytnwiqktiqak

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6qhbB (B:)
lvhggpcdktshpyqaalytsghllcggvlihplwvltaahckkpnlqvflgkhnlgqqe
ssqeqssvvravihpdydaashdqdimllrlarpaklseliqplplerdcsaqttschil
gwgktadgdfpdtiqcayihlvsreecehaypgqitqnmlcagdekygkdscqgdsggpl
vcgdhlrglvswgnipcgskekpgvytnvcrytnwiqktiqak

    Sequence, based on observed residues (ATOM records): (download) 
    >6qhbB (B:)
lvhggpcdktshpyqaalytsghllcggvlihplwvltaahckkpnlqvflgkhnlgqqe
ssqeqssvvravihpdydaashdqdimllrlarpaklseliqplplerdcsaqttschil
gwgktadgdfpdtiqcayihlvsreecehaypgqitqnmlcagdekygkdscqgdsggpl
vcgdhlrglvswgnipcgskekpgvytnvcrytnwiqktiqa