PDB entry 6qgj

View 6qgj on RCSB PDB site
Description: Structure of human Bcl-2 in complex with fragment/ABT-263 hybrid
Class: apoptosis
Keywords: APOPTOSIS, BCL2, ABT-763, Drug design
Deposited on 2019-01-11, released 2019-06-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-09-18, with a file datestamp of 2019-09-13.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2L1, BCL2L, BCLX
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415
      • engineered mutation (13)
    • Uniprot Q07817 (Start-42)
    • Uniprot P10415 (43-154)
      • engineered mutation (46)
      • engineered mutation (57)
      • engineered mutation (75)
      • engineered mutation (78-80)
      • engineered mutation (119)
      • engineered mutation (126)
      • engineered mutation (129-130)
      • engineered mutation (134)
    • Uniprot Q07817 (155-End)
    Domains in SCOPe 2.08: d6qgja_
  • Heterogens: J1T, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6qgjA (A:)
msqdnreivmkyisyklsqrgyewdagdveenrteapegtesevvhqtlrqagddfslry
rrdfaemssqlhltpgtayasfatvveelfrdgvnwgrivaffefggvmcvesvnremsv
lvdniaawmatylndhlhtwiqdnggwdafvelygnnaaaesrkgqerflehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6qgjA (A:)
nreivmkyisyklsqrgyewesevvhqtlrqagddfslryrrdfaemssqlhltpgtaya
sfatvveelfrdgvnwgrivaffefggvmcvesvnremsvlvdniaawmatylndhlhtw
iqdnggwdafvelygnnaaaesrkgq