PDB entry 6qfg

View 6qfg on RCSB PDB site
Description: Crystal Structure of Human Kallikrein 6 (I218Y) in complex with GSK144
Class: hydrolase
Keywords: Protease, Inhibitor, Complex, HYDROLASE
Deposited on 2019-01-10, released 2019-05-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 1.68 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kallikrein-6
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK6, PRSS18, PRSS9
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92876 (0-222)
      • engineered mutation (56)
      • engineered mutation (58)
      • engineered mutation (112)
      • engineered mutation (194)
    Domains in SCOPe 2.07: d6qfga_
  • Chain 'B':
    Compound: Kallikrein-6
    Species: Homo sapiens [TaxId:9606]
    Gene: KLK6, PRSS18, PRSS9
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92876 (0-End)
      • engineered mutation (56)
      • engineered mutation (58)
      • engineered mutation (112)
      • engineered mutation (194)
    Domains in SCOPe 2.07: d6qfgb_
  • Heterogens: J08, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6qfgA (A:)
lvhggpcdktshpyqaalytsghllcggvlihplwvltaahckkpnlqvflgkhnlgqqe
ssqeqssvvravihpdydaashdqdimllrlarpaklseliqplplerdcsaqttschil
gwgktadgdfpdtiqcayihlvsreecehaypgqitqnmlcagdekygkdscqgdsggpl
vcgdhlrglvswgnypcgskekpgvytnvcrytnwiqktiqak

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6qfgB (B:)
lvhggpcdktshpyqaalytsghllcggvlihplwvltaahckkpnlqvflgkhnlgqqe
ssqeqssvvravihpdydaashdqdimllrlarpaklseliqplplerdcsaqttschil
gwgktadgdfpdtiqcayihlvsreecehaypgqitqnmlcagdekygkdscqgdsggpl
vcgdhlrglvswgnypcgskekpgvytnvcrytnwiqktiqak

    Sequence, based on observed residues (ATOM records): (download) 
    >6qfgB (B:)
lvhggpcdktshpyqaalytsghllcggvlihplwvltaahckkpnlqvflgkhnlgqqe
ssqeqssvvravihpdydaashdqdimllrlarpaklseliqplplerdcsaqttschil
gwgktadgdfpdtiqcayihlvsreecehaypgqitqnmlcagdekygkdscqgdsggpl
vcgdhlrglvswgnypcgskekpgvytnvcrytnwiqktiqa