PDB entry 6qfc

View 6qfc on RCSB PDB site
Description: Structure of an anti-Mcl1 scFv
Class: apoptosis
Keywords: Mcl1, scFv, APOPTOSIS
Deposited on 2019-01-09, released 2019-11-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-13, with a file datestamp of 2019-11-08.
Experiment type: XRAY
Resolution: 1.96 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (8-End)
      • expression tag (6-7)
      • conflict (27)
      • conflict (39-40)
      • conflict (42)
    Domains in SCOPe 2.08: d6qfca1, d6qfca2
  • Chain 'B':
    Compound: scFv55
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6QFC (0-End)
    Domains in SCOPe 2.08: d6qfcb1, d6qfcb2, d6qfcb3
  • Heterogens: DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6qfcA (A:)
gplgseddlyrqsleiisrylreqatgskdskplgeagaagrraletlrrvgdgvqrnhe
tafqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqes
cieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg

    Sequence, based on observed residues (ATOM records): (download) 
    >6qfcA (A:)
ddlyrqsleiisrylreqatgskdaagrraletlrrvgdgvqrnhetafqgmlrkldikn
eddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesitdvlv
rtkrdwlvkqrgwdgfveffhv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6qfcB (B:)
qvtlkesggglvkpggslrlscaasgftfssysmnwvrqapgkglewvssisssssyiyy
adsvkgrftisrdnaknslylqmnslraedtavyycarqvgatwafdiwgqgtlvtvssg
gggsggggsggggsaqsvltqppsasgtpgqrvtiscsgsssnigsntvnwyqqlpgtap
klliysnnqrpsgvpdrfsgsksgtsaslaisglqsedeadyycaawddslnawvfgggt
kltvlgaaaenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6qfcB (B:)
qvtlkesggglvkpggslrlscaasgftfssysmnwvrqapgkglewvssisssssyiyy
adsvkgrftisrdnaknslylqmnslraedtavyycarqvgatwafdiwgqgtlvtvssv
ltqppsasgtpgqrvtiscsgsssnigsntvnwyqqlpgtapklliysnnqrpsgvpdrf
sgsksgtsaslaisglqsedeadyycaawddslnawvfgggtkltvlgaaaenlyf