PDB entry 6qfb

View 6qfb on RCSB PDB site
Description: structure of the human atp citrate lyase holoenzyme in complex with citrate, coenzyme a and mg.adp
Deposited on 2019-01-09, released 2019-04-10
The last revision was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 3.25 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ATP-citrate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACLY
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: ATP-citrate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACLY
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: ATP-citrate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACLY
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: ATP-citrate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACLY
    Database cross-references and differences (RAF-indexed):
  • Heterogens: MG, FLC, COA, ADP, 2HP

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6qfbA (A:)
msakaiseqtgkellykficttsaiqnrfkyarvtpdtdwarllqdhpwllsqnlvvkpd
qlikrrgklglvgvnltldgvkswlkprlgqeatvgkatgflknfliepfvphsqaeefy
vciyatregdyvlfhheggvdvgdvdakaqkllvgvdeklnpedikkhllvhapedkkei
lasfisglfnfyedlyftyleinplvvtkdgvyvldlaakvdatadyickvkwgdiefpp
pfgreaypeeayiadldaksgaslkltllnpkgriwtmvagggasvvysdticdlggvne
lanygeysgapseqqtydyaktilslmtrekhpdgkiliiggsianftnvaatfkgivra
irdyqgplkehevtifvrrggpnyqeglrvmgevgkttgipihvfgtethmtaivgmalg
hrpipmgksttlfsrhtkaivwgmqtravqgmldfdyvcsrdepsvaamvypftgdhkqk
fywghkeilipvfknmadamrkhpevdvlinfaslrsaydstmetmnyaqirtiaiiaeg
ipealtrklikkadqkgvtiigpatvggikpgcfkigntggmldnilasklyrpgsvayv
srsggmsnelnniisrttdgvyegvaiggdrypgstfmdhvlryqdtpgvkmivvlgeig
gteeykicrgikegrltkpivcwcigtcatmfssevqfghagacanqasetavaknqalk
eagvfvprsfdelgeiiqsvyedlvangvivpaqevppptvpmdyswarelglirkpasf
mtsicdergqeliyagmpitevfkeemgiggvlgllwfqkrlpkyscqfiemclmvtadh
gpavsgahntiicaragkdlvssltsglltigdrfggaldaaakmfskafdsgiipmefv
nkmkkegklimgighrvksinnpdmrvqilkdyvrqhfpatplldyalevekittskkpn
lilnvdgligvafvdmlrncgsftreeadeyidigalngifvlgrsmgfighyldqkrlk
qglyrhpwddisyvlpehmsmggshhhhhh

    Sequence, based on observed residues (ATOM records):
    >6qfbA (A:)
sakaiseqtgkellykficttsaiqnrfkyarvtpdtdwarllqdhpwllsqnlvvkpdq
likrrgklglvgvnltldgvkswlkprlgqeatvgkatgflknfliepfvphsqaeefyv
ciyatregdyvlfhheggvdvgdvdakaqkllvgvdeklnpedikkhllvhapedkkeil
asfisglfnfyedlyftyleinplvvtkdgvyvldlaakvdatadyickvkwgdiefppp
fgreaypeeayiadldaksgaslkltllnpkgriwtmvagggasvvysdticdlggvnel
anygeysgapseqqtydyaktilslmtrekhpdgkiliiggsianftnvaatfkgivrai
rdyqgplkehevtifvrrggpnyqeglrvmgevgkttgipihvfgtethmtaivgmalgh
rpipksttlfsrhtkaivwgmqtravqgmldfdyvcsrdepsvaamvypftgdhkqkfyw
ghkeilipvfknmadamrkhpevdvlinfaslrsaydstmetmnyaqirtiaiiaegipe
altrklikkadqkgvtiigpatvggikpgcfkigntggmldnilasklyrpgsvayvsrs
ggmsnelnniisrttdgvyegvaiggdrypgstfmdhvlryqdtpgvkmivvlgeiggte
eykicrgikegrltkpivcwcigtcatmfasetavaknqalkeagvfvprsfdelgeiiq
svyedlvangvivpaqevppptvpmdyswarelglirkpasfmtsicdergqeliyagmp
itevfkeemgiggvlgllwfqkrlpkyscqfiemclmvtadhgpavsgahntiicaragk
dlvssltsglltigdrfggaldaaakmfskafdsgiipmefvnkmkkegklimgighrvk
sinnpdmrvqilkdyvrqhfpatplldyalevekittskkpnlilnvdgligvafvdmlr
ncgsftreeadeyidigalngifvlgrsmgfighyldqkrlkqglyrhpwddisyvlpe

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6qfbB (B:)
msakaiseqtgkellykficttsaiqnrfkyarvtpdtdwarllqdhpwllsqnlvvkpd
qlikrrgklglvgvnltldgvkswlkprlgqeatvgkatgflknfliepfvphsqaeefy
vciyatregdyvlfhheggvdvgdvdakaqkllvgvdeklnpedikkhllvhapedkkei
lasfisglfnfyedlyftyleinplvvtkdgvyvldlaakvdatadyickvkwgdiefpp
pfgreaypeeayiadldaksgaslkltllnpkgriwtmvagggasvvysdticdlggvne
lanygeysgapseqqtydyaktilslmtrekhpdgkiliiggsianftnvaatfkgivra
irdyqgplkehevtifvrrggpnyqeglrvmgevgkttgipihvfgtethmtaivgmalg
hrpipmgksttlfsrhtkaivwgmqtravqgmldfdyvcsrdepsvaamvypftgdhkqk
fywghkeilipvfknmadamrkhpevdvlinfaslrsaydstmetmnyaqirtiaiiaeg
ipealtrklikkadqkgvtiigpatvggikpgcfkigntggmldnilasklyrpgsvayv
srsggmsnelnniisrttdgvyegvaiggdrypgstfmdhvlryqdtpgvkmivvlgeig
gteeykicrgikegrltkpivcwcigtcatmfssevqfghagacanqasetavaknqalk
eagvfvprsfdelgeiiqsvyedlvangvivpaqevppptvpmdyswarelglirkpasf
mtsicdergqeliyagmpitevfkeemgiggvlgllwfqkrlpkyscqfiemclmvtadh
gpavsgahntiicaragkdlvssltsglltigdrfggaldaaakmfskafdsgiipmefv
nkmkkegklimgighrvksinnpdmrvqilkdyvrqhfpatplldyalevekittskkpn
lilnvdgligvafvdmlrncgsftreeadeyidigalngifvlgrsmgfighyldqkrlk
qglyrhpwddisyvlpehmsmggshhhhhh

    Sequence, based on observed residues (ATOM records):
    >6qfbB (B:)
sakaiseqtgkellykficttsaiqnrfkyarvtpdtdwarllqdhpwllsqnlvvkpdq
likrrgklglvgvnltldgvkswlkprlgqeatvgkatgflknfliepfvphsqaeefyv
ciyatregdyvlfhheggvdvgdvdakaqkllvgvdeklnpedikkhllvhapedkkeil
asfisglfnfyedlyftyleinplvvtkdgvyvldlaakvdatadyickvkwgdiefppp
fgreaypeeayiadldaksgaslkltllnpkgriwtmvagggasvvysdticdlggvnel
anygeysgapseqqtydyaktilslmtrekhpdgkiliiggsianftnvaatfkgivrai
rdyqgplkehevtifvrrggpnyqeglrvmgevgkttgipihvfgtethmtaivgmalgh
rpipksttlfsrhtkaivwgmqtravqgmldfdyvcsrdepsvaamvypftgdhkqkfyw
ghkeilipvfknmadamrkhpevdvlinfaslrsaydstmetmnyaqirtiaiiaegipe
altrklikkadqkgvtiigpatvggikpgcfkigntggmldnilasklyrpgsvayvsrs
ggmsnelnniisrttdgvyegvaiggdrypgstfmdhvlryqdtpgvkmivvlgeiggte
eykicrgikegrltkpivcwcigtcatmfssevqfghagacanqasetavaknqalkeag
vfvprsfdelgeiiqsvyedlvangvivpaqevppptvpmdyswarelglirkpasfmts
icdergqeliyagmpitevfkeemgiggvlgllwfqkrlpkyscqfiemclmvtadhgpa
vsgahntiicaragkdlvssltsglltigdrfggaldaaakmfskafdsgiipmefvnkm
kkegklimgighrvksinnpdmrvqilkdyvrqhfpatplldyalevekittskkpnlil
nvdgligvafvdmlrncgsftreeadeyidigalngifvlgrsmgfighyldqkrlkqgl
yrhpwddisyvlpeh

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6qfbC (C:)
msakaiseqtgkellykficttsaiqnrfkyarvtpdtdwarllqdhpwllsqnlvvkpd
qlikrrgklglvgvnltldgvkswlkprlgqeatvgkatgflknfliepfvphsqaeefy
vciyatregdyvlfhheggvdvgdvdakaqkllvgvdeklnpedikkhllvhapedkkei
lasfisglfnfyedlyftyleinplvvtkdgvyvldlaakvdatadyickvkwgdiefpp
pfgreaypeeayiadldaksgaslkltllnpkgriwtmvagggasvvysdticdlggvne
lanygeysgapseqqtydyaktilslmtrekhpdgkiliiggsianftnvaatfkgivra
irdyqgplkehevtifvrrggpnyqeglrvmgevgkttgipihvfgtethmtaivgmalg
hrpipmgksttlfsrhtkaivwgmqtravqgmldfdyvcsrdepsvaamvypftgdhkqk
fywghkeilipvfknmadamrkhpevdvlinfaslrsaydstmetmnyaqirtiaiiaeg
ipealtrklikkadqkgvtiigpatvggikpgcfkigntggmldnilasklyrpgsvayv
srsggmsnelnniisrttdgvyegvaiggdrypgstfmdhvlryqdtpgvkmivvlgeig
gteeykicrgikegrltkpivcwcigtcatmfssevqfghagacanqasetavaknqalk
eagvfvprsfdelgeiiqsvyedlvangvivpaqevppptvpmdyswarelglirkpasf
mtsicdergqeliyagmpitevfkeemgiggvlgllwfqkrlpkyscqfiemclmvtadh
gpavsgahntiicaragkdlvssltsglltigdrfggaldaaakmfskafdsgiipmefv
nkmkkegklimgighrvksinnpdmrvqilkdyvrqhfpatplldyalevekittskkpn
lilnvdgligvafvdmlrncgsftreeadeyidigalngifvlgrsmgfighyldqkrlk
qglyrhpwddisyvlpehmsmggshhhhhh

    Sequence, based on observed residues (ATOM records):
    >6qfbC (C:)
sakaiseqtgkellykficttsaiqnrfkyarvtpdtdwarllqdhpwllsqnlvvkpdq
likrrgklglvgvnltldgvkswlkprlgqeatvgkatgflknfliepfvphsqaeefyv
ciyatregdyvlfhheggvdvgdvdakaqkllvgvdeklnpedikkhllvhapedkkeil
asfisglfnfyedlyftyleinplvvtkdgvyvldlaakvdatadyickvkwgdiefppp
fgrepeeayiadldaksgaslkltllnpkgriwtmvagggasvvysdticdlggvnelan
ygeysgapseqqtydyaktilslmtrekhpdgkiliiggsianftnvaatfkgivraird
yqgplkehevtifvrrggpnyqeglrvmgevgkttgipihvfgtethmtaivgmalghks
ttlfsrhtkaivwgmqtravqgmldfdyvcsrdepsvaamvypftgdhkqkfywghkeil
ipvfknmadamrkhpevdvlinfaslrsaydstmetmnyaqirtiaiiaegipealtrkl
ikkadqkgvtiigpatvggikpgcfkigntggmldnilasklyrpgsvayvsrsggmsne
lnniisrttdgvyegvaiggdrypgstfmdhvlryqdtpgvkmivvlgeiggteeykicr
gikegrltkpivcwcigtcatmfasetavaknqalkeagvfvprsfdelgeiiqsvyedl
vangvivpaqevppptvpmdyswarelglirkpasfmtsicdergqeliyagmpitevfk
eemgiggvlgllwfqkrlpkyscqfiemclmvtadhgpavsgahntiicaragkdlvssl
tsglltigdrfggaldaaakmfskafdsgiipmefvnkmkkegklimgighrvksinnpd
mrvqilkdyvrqhfpatplldyalevekittskkpnlilnvdgligvafvdmlrncgsft
reeadeyidigalngifvlgrsmgfighyldqkrlkqglyrhpwddisyvl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6qfbD (D:)
msakaiseqtgkellykficttsaiqnrfkyarvtpdtdwarllqdhpwllsqnlvvkpd
qlikrrgklglvgvnltldgvkswlkprlgqeatvgkatgflknfliepfvphsqaeefy
vciyatregdyvlfhheggvdvgdvdakaqkllvgvdeklnpedikkhllvhapedkkei
lasfisglfnfyedlyftyleinplvvtkdgvyvldlaakvdatadyickvkwgdiefpp
pfgreaypeeayiadldaksgaslkltllnpkgriwtmvagggasvvysdticdlggvne
lanygeysgapseqqtydyaktilslmtrekhpdgkiliiggsianftnvaatfkgivra
irdyqgplkehevtifvrrggpnyqeglrvmgevgkttgipihvfgtethmtaivgmalg
hrpipmgksttlfsrhtkaivwgmqtravqgmldfdyvcsrdepsvaamvypftgdhkqk
fywghkeilipvfknmadamrkhpevdvlinfaslrsaydstmetmnyaqirtiaiiaeg
ipealtrklikkadqkgvtiigpatvggikpgcfkigntggmldnilasklyrpgsvayv
srsggmsnelnniisrttdgvyegvaiggdrypgstfmdhvlryqdtpgvkmivvlgeig
gteeykicrgikegrltkpivcwcigtcatmfssevqfghagacanqasetavaknqalk
eagvfvprsfdelgeiiqsvyedlvangvivpaqevppptvpmdyswarelglirkpasf
mtsicdergqeliyagmpitevfkeemgiggvlgllwfqkrlpkyscqfiemclmvtadh
gpavsgahntiicaragkdlvssltsglltigdrfggaldaaakmfskafdsgiipmefv
nkmkkegklimgighrvksinnpdmrvqilkdyvrqhfpatplldyalevekittskkpn
lilnvdgligvafvdmlrncgsftreeadeyidigalngifvlgrsmgfighyldqkrlk
qglyrhpwddisyvlpehmsmggshhhhhh

    Sequence, based on observed residues (ATOM records):
    >6qfbD (D:)
sakaiseqtgkellykficttsaiqnrfkyarvtpdtdwarllqdhpwllsqnlvvkpdq
likrrgklglvgvnltldgvkswlkprlgqeatvgkatgflknfliepfvphsqaeefyv
ciyatregdyvlfhheggvdvgdvdakaqkllvgvdeklnpedikkhllvhapedkkeil
asfisglfnfyedlyftyleinplvvtkdgvyvldlaakvdatadyickvkwgdiefppp
fgreaypeeayiadldaksgaslkltllnpkgriwtmvagggasvvysdticdlggvnel
anygeysgapseqqtydyaktilslmtrekhpdgkiliiggsianftnvaatfkgivrai
rdyqgplkehevtifvrrggpnyqeglrvmgevgkttgipihvfgtethmtaivgmalgh
rpipksttlfsrhtkaivwgmqtravqgmldfdyvcsrdepsvaamvypftgdhkqkfyw
ghkeilipvfknmadamrkhpevdvlinfaslrsaydstmetmnyaqirtiaiiaegipe
altrklikkadqkgvtiigpatvggikpgcfkigntggmldnilasklyrpgsvayvsrs
ggmsnelnniisrttdgvyegvaiggdrypgstfmdhvlryqdtpgvkmivvlgeiggte
eykicrgikegrltkpivcwcigtcatmfsqasetavaknqalkeagvfvprsfdelgei
iqsvyedlvangvivpaqevppptvpmdyswarelglirkpasfmtsicdergqeliyag
mpitevfkeemgiggvlgllwfqkrlpkyscqfiemclmvtadhgpavsgahntiicara
gkdlvssltsglltigdrfggaldaaakmfskafdsgiipmefvnkmkkegklimgighr
vksinnpdmrvqilkdyvrqhfpatplldyalevekittskkpnlilnvdgligvafvdm
lrncgsftreeadeyidigalngifvlgrsmgfighyldqkrlkqglyrhpwddisyvlp
ehmsm