PDB entry 6q6k

View 6q6k on RCSB PDB site
Description: Crystal structure of recombinant human beta-glucocerebrosidase in complex with cyclophellitol activity based probe with Cy5 tag (ME569)
Class: hydrolase
Keywords: hydrolase, retaining beta-glucosidase
Deposited on 2018-12-11, released 2019-03-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 1.92 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Gene: GBA, GC, GLUC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (0-496)
      • conflict (494)
    Domains in SCOPe 2.08: d6q6ka1, d6q6ka2
  • Chain 'B':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Gene: GBA, GC, GLUC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (0-496)
      • conflict (494)
    Domains in SCOPe 2.08: d6q6kb1, d6q6kb2
  • Heterogens: HKW, ACT, SO4, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6q6kA (A:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

    Sequence, based on observed residues (ATOM records): (download) 
    >6q6kA (A:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvskfweqsvrlgswdrgm
qyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhlg
hfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfle
tispgysihtylwhrq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6q6kB (B:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

    Sequence, based on observed residues (ATOM records): (download) 
    >6q6kB (B:)
arpcipksfgyssvvcvcnatycdsfdppalgtfsryestrsgrrmelsmgpiqanhtgt
gllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniirvpm
ascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwtspt
wlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagllsg
ypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpeaak
yvhgiavhwyldflapakatlgethrlfpntmlfaseacvgseqsvrlgswdrgmqyshs
iitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhlghfskf
ipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfletispg
ysihtylwhrq