PDB entry 6q4o

View 6q4o on RCSB PDB site
Description: fusidic acid bound acrb_i27a
Deposited on 2018-12-06, released 2019-11-13
The last revision was dated 2020-05-27, with a file datestamp of 2020-05-22.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Multidrug efflux pump subunit AcrB
    Species: Escherichia coli K-12 [TaxId:83333]
    Gene: acrB, acrE, b0462, JW0451
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31224 (0-End)
      • engineered mutation (26)
  • Chain 'B':
    Compound: Multidrug efflux pump subunit AcrB
    Species: Escherichia coli K-12 [TaxId:83333]
    Gene: acrB, acrE, b0462, JW0451
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31224 (0-End)
      • engineered mutation (26)
  • Chain 'C':
    Compound: Multidrug efflux pump subunit AcrB
    Species: Escherichia coli K-12 [TaxId:83333]
    Gene: acrB, acrE, b0462, JW0451
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31224 (0-End)
      • engineered mutation (26)
  • Chain 'D':
    Compound: darpin
    Species: synthetic construct, synthetic [TaxId:32630]
    Gene: artificial gene
    Database cross-references and differences (RAF-indexed):
    • PDB 6Q4O
  • Chain 'E':
    Compound: darpin
    Species: synthetic construct, synthetic [TaxId:32630]
    Gene: artificial gene
    Database cross-references and differences (RAF-indexed):
    • PDB 6Q4O
  • Heterogens: FUA, LMT, D10, DDQ, GOL, HEX, OCT, D12, DDR, PTY, SO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6q4oA (A:)
mpnffidrpifawviaiiimlagglaalklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfagrgqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfsrknediehshtvdhhlehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q4oA (A:)
mpnffidrpifawviaiiimlagglaalklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfagrgqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfsrknedieh

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6q4oB (B:)
mpnffidrpifawviaiiimlagglaalklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfagrgqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfsrknediehshtvdhhlehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q4oB (B:)
mpnffidrpifawviaiiimlagglaalklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfagrgqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfs

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6q4oC (C:)
mpnffidrpifawviaiiimlagglaalklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfagrgqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfsrknediehshtvdhhlehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q4oC (C:)
mpnffidrpifawviaiiimlagglaalklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfagrgqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfsr

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6q4oD (D:)
mrgshhhhhhgsdlgkklleaaragrddevrilmangadvnaadvvgwtplhlaaywghl
eivevllkngadvnaydtlgstplhlaahfghleivevllkngadvnakddngitplhla
anrghleivevllkygadvnaqdkfgktafdisinngnedlaeilqkln

    Sequence, based on observed residues (ATOM records):
    >6q4oD (D:)
sdlgkklleaaragrddevrilmangadvnaadvvgwtplhlaaywghleivevllknga
dvnaydtlgstplhlaahfghleivevllkngadvnakddngitplhlaanrghleivev
llkygadvnaqdkfgktafdisinngnedlaeilqk

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6q4oE (E:)
mrgshhhhhhgsdlgkklleaaragrddevrilmangadvnaadvvgwtplhlaaywghl
eivevllkngadvnaydtlgstplhlaahfghleivevllkngadvnakddngitplhla
anrghleivevllkygadvnaqdkfgktafdisinngnedlaeilqkln

    Sequence, based on observed residues (ATOM records):
    >6q4oE (E:)
dlgkklleaaragrddevrilmangadvnaadvvgwtplhlaaywghleivevllkngad
vnaydtlgstplhlaahfghleivevllkngadvnakddngitplhlaanrghleivevl
lkygadvnaqdkfgktafdisinngnedlaeilq