PDB entry 6q2r

View 6q2r on RCSB PDB site
Description: cryo-em structure of ret/gfra2/nrtn extracellular complex in the tetrameric form
Deposited on 2019-08-08, released 2019-10-02
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: EM
Resolution: 4.3 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neurturin
    Species: Homo sapiens [TaxId:9606]
    Gene: NRTN
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Neurturin
    Species: Homo sapiens [TaxId:9606]
    Gene: NRTN
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: GDNF family receptor alpha-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GFRA2, GDNFRB, RETL2, TRNR2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: GDNF family receptor alpha-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GFRA2, GDNFRB, RETL2, TRNR2
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Gene: RET, CDHF12, CDHR16, PTC, RET51
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07949 (0-End)
      • conflict (85)
  • Chain 'F':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Gene: RET, CDHF12, CDHR16, PTC, RET51
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07949 (0-End)
      • conflict (85)
  • Chain 'U':
    Compound: Neurturin
    Species: Homo sapiens [TaxId:9606]
    Gene: NRTN
    Database cross-references and differences (RAF-indexed):
  • Chain 'V':
    Compound: Neurturin
    Species: Homo sapiens [TaxId:9606]
    Gene: NRTN
    Database cross-references and differences (RAF-indexed):
  • Chain 'W':
    Compound: GDNF family receptor alpha-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GFRA2, GDNFRB, RETL2, TRNR2
    Database cross-references and differences (RAF-indexed):
  • Chain 'X':
    Compound: GDNF family receptor alpha-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GFRA2, GDNFRB, RETL2, TRNR2
    Database cross-references and differences (RAF-indexed):
  • Chain 'Y':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Gene: RET, CDHF12, CDHR16, PTC, RET51
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07949 (0-End)
      • conflict (85)
  • Chain 'Z':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Gene: RET, CDHF12, CDHR16, PTC, RET51
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07949 (0-End)
      • conflict (85)
  • Heterogens: CA, NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6q2rA (A:)
arlgarpcglrelevrvselglgyasdetvlfrycagaceaaarvydlglrrlrqrrrlr
rervraqpccrptayedevsfldahsryhtvhelsarecacv

    Sequence, based on observed residues (ATOM records):
    >6q2rA (A:)
arpcglrelevrvselglgyasdetvlfrycagaceaaarvydlglrrlrqrrrlrrerv
raqpccrptayedevsfldahsryhtvhelsarecacv

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6q2rB (B:)
arlgarpcglrelevrvselglgyasdetvlfrycagaceaaarvydlglrrlrqrrrlr
rervraqpccrptayedevsfldahsryhtvhelsarecacv

    Sequence, based on observed residues (ATOM records):
    >6q2rB (B:)
arpcglrelevrvselglgyasdetvlfrycagaceaaarvydlglrrlrqrrrlrrerv
raqpccrptayedevsfldahsryhtvhelsarecacv

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6q2rC (C:)
sslqgpelhgwrppvdcvranelcaaesncssryrtlrqclagrdrntmlankecqaale
vlqesplydcrckrgmkkelqclqiywsihlgltegeefyeaspyepvtsrlsdifrlas
ifsgtgadpvvsaksnhcldaakacnlndnckklrssyisicnreisptercnrrkchka
lrqffdrvpseytyrmlfcscqdqacaerrrqtilpscsyedkekpncldlrgvcrtdhl
crsrladfhancrasyqtvtscpadnyqaclgsyagmigfdmtpnyvdssptgivvspwc
scrgsgnmeeecekflrdftenpclrnaiqafgngtdvngthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q2rC (C:)
pvdcvranelcaaesncssryrtlrqclankecqaalevlqesplydcrckrgmkkelqc
lqiywsihlgefyeaspyepvnhcldaakacnlndnckklrssyisicnreisptercnr
rkchkalrqffdrvpseytyrmlfcscqdqacaerrrqtilpscsyedkekpncldlrgv
crtdhlcrsrladfhancrasyqtvtscpadnyqaclgsyagmigfdmtpnyvdssptgi
vvspwcscrgsgnmeeecekflrdftenpclrnaiqafgn

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6q2rD (D:)
sslqgpelhgwrppvdcvranelcaaesncssryrtlrqclagrdrntmlankecqaale
vlqesplydcrckrgmkkelqclqiywsihlgltegeefyeaspyepvtsrlsdifrlas
ifsgtgadpvvsaksnhcldaakacnlndnckklrssyisicnreisptercnrrkchka
lrqffdrvpseytyrmlfcscqdqacaerrrqtilpscsyedkekpncldlrgvcrtdhl
crsrladfhancrasyqtvtscpadnyqaclgsyagmigfdmtpnyvdssptgivvspwc
scrgsgnmeeecekflrdftenpclrnaiqafgngtdvngthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q2rD (D:)
pvdcvranelcaaesncssryrtlrqclankecqaalevlqesplydcrckrgmkkelqc
lqiywsihlgefyeaspyepvnhcldaakacnlndnckklrssyisicnreisptercnr
rkchkalrqffdrvpseytyrmlfcscqdqacaerrrqtilpscsyedkekpncldlrgv
crtdhlcrsrladfhancrasyqtvtscpadnyqaclgsyagmigfdmtpnyvdssptgi
vvspwcscrgsgnmeeecekflrdftenpclrnaiqafgn

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6q2rE (E:)
lyfsrdayweklyvdqaagtpllyvhalrdapeevpsfrlgqhlygtyrtrlhennwici
qedtgllylnrsldhssweklsvrnhgfplltvylkvflsptslregecqwpgcarvyfs
ffntsfpacsslkprelcfpetrpsfrirenrppgtfhqfrllpvqflcpnisvayrlle
geglpfrcapdslevstrwaldreqrekyelvavctvhagareevvmvpfpvtvydedds
aptfpagvdtasavvefkrkedtvvatlrvfdadvvpasgelvrrytstllpgdtwaqqt
frvehwpnetsvqangsfvratvhdyrlvlnrnlsisenrtmqlavlvndsdfqgpgagv
lllhfnvsvlpvslhlpstyslsvsrrarrfaqigkvcvencqafsginvqyklhssgan
cstlgvvtsaedtsgilfvndtkalrrpkcaelhymvvatdqqtsrqaqaqllvtvegsy
vaeeagcplscavskrrleceecgglgsptgrcewrqgdgkgitrnfstcspstktcpdg
hcdvvetqdinicpqdclrgsivgghepgeprgikagygtcncfpeeekcfcepediqdp
lcdelcrgthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q2rE (E:)
lyfsrdayweklyvdqaagtpllyvhalrdapeevpsfrlgqhlygtyrtrlhennwici
qedtgllylnrsldhssweklsvrnhgfplltvylkvflscqwpgcarvyfsffntsfpa
csslkprelcfpetrpsfrirenrppgtfhqfrllpvqflcpnisvayrllglpfrcapd
slevstrwaldreqrekyelvavctvheevvmvpfpvtvydeddsaptfpagvdtasavv
efkrkedtvvatlrvfdadvvpasgelvrrytstllpgdtwaqqtfrvehwpnetsvqan
gsfvratvhdyrlvlnrnlsisenrtmqlavlvndsgvlllhfnvsvlpvslhlpstysl
svsrrarrfaqigkvcvencqafsginvqyklhssgancstlgvvtsaedtsgilfvndt
kalrrpkcaelhymvvatdqqtsrqaqaqllvtvegsyvaeeagcplscavskrrlecee
cgglgsptgrcewrqgdgkgitrnfstcspstktcpdghcdvvetqdinicpqdclrgsi
vgghepgeprgikagygtcncfpeeekcfcep

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6q2rF (F:)
lyfsrdayweklyvdqaagtpllyvhalrdapeevpsfrlgqhlygtyrtrlhennwici
qedtgllylnrsldhssweklsvrnhgfplltvylkvflsptslregecqwpgcarvyfs
ffntsfpacsslkprelcfpetrpsfrirenrppgtfhqfrllpvqflcpnisvayrlle
geglpfrcapdslevstrwaldreqrekyelvavctvhagareevvmvpfpvtvydedds
aptfpagvdtasavvefkrkedtvvatlrvfdadvvpasgelvrrytstllpgdtwaqqt
frvehwpnetsvqangsfvratvhdyrlvlnrnlsisenrtmqlavlvndsdfqgpgagv
lllhfnvsvlpvslhlpstyslsvsrrarrfaqigkvcvencqafsginvqyklhssgan
cstlgvvtsaedtsgilfvndtkalrrpkcaelhymvvatdqqtsrqaqaqllvtvegsy
vaeeagcplscavskrrleceecgglgsptgrcewrqgdgkgitrnfstcspstktcpdg
hcdvvetqdinicpqdclrgsivgghepgeprgikagygtcncfpeeekcfcepediqdp
lcdelcrgthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q2rF (F:)
lyfsrdayweklyvdqaagtpllyvhalrdapeevpsfrlgqhlygtyrtrlhennwici
qedtgllylnrsldhssweklsvrnhgfplltvylkvflscqwpgcarvyfsffntsfpa
csslkprelcfpetrpsfrirenrppgtfhqfrllpvqflcpnisvayrllglpfrcapd
slevstrwaldreqrekyelvavctvheevvmvpfpvtvydeddsaptfpagvdtasavv
efkrkedtvvatlrvfdadvvpasgelvrrytstllpgdtwaqqtfrvehwpnetsvqan
gsfvratvhdyrlvlnrnlsisenrtmqlavlvndsgvlllhfnvsvlpvslhlpstysl
svsrrarrfaqigkvcvencqafsginvqyklhssgancstlgvvtsaedtsgilfvndt
kalrrpkcaelhymvvatdqqtsrqaqaqllvtvegsyvaeeagcplscavskrrlecee
cgglgsptgrcewrqgdgkgitrnfstcspstktcpdghcdvvetqdinicpqdclrgsi
vgghepgeprgikagygtcncfpeeekcfcep

  • Chain 'U':
    Sequence, based on SEQRES records:
    >6q2rU (U:)
arlgarpcglrelevrvselglgyasdetvlfrycagaceaaarvydlglrrlrqrrrlr
rervraqpccrptayedevsfldahsryhtvhelsarecacv

    Sequence, based on observed residues (ATOM records):
    >6q2rU (U:)
arpcglrelevrvselglgyasdetvlfrycagaceaaarvydlglrrlrqrrrlrrerv
raqpccrptayedevsfldahsryhtvhelsarecacv

  • Chain 'V':
    Sequence, based on SEQRES records:
    >6q2rV (V:)
arlgarpcglrelevrvselglgyasdetvlfrycagaceaaarvydlglrrlrqrrrlr
rervraqpccrptayedevsfldahsryhtvhelsarecacv

    Sequence, based on observed residues (ATOM records):
    >6q2rV (V:)
arpcglrelevrvselglgyasdetvlfrycagaceaaarvydlglrrlrqrrrlrrerv
raqpccrptayedevsfldahsryhtvhelsarecacv

  • Chain 'W':
    Sequence, based on SEQRES records:
    >6q2rW (W:)
sslqgpelhgwrppvdcvranelcaaesncssryrtlrqclagrdrntmlankecqaale
vlqesplydcrckrgmkkelqclqiywsihlgltegeefyeaspyepvtsrlsdifrlas
ifsgtgadpvvsaksnhcldaakacnlndnckklrssyisicnreisptercnrrkchka
lrqffdrvpseytyrmlfcscqdqacaerrrqtilpscsyedkekpncldlrgvcrtdhl
crsrladfhancrasyqtvtscpadnyqaclgsyagmigfdmtpnyvdssptgivvspwc
scrgsgnmeeecekflrdftenpclrnaiqafgngtdvngthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q2rW (W:)
pvdcvranelcaaesncssryrtlrqclankecqaalevlqesplydcrckrgmkkelqc
lqiywsihlgefyeaspyepvnhcldaakacnlndnckklrssyisicnreisptercnr
rkchkalrqffdrvpseytyrmlfcscqdqacaerrrqtilpscsyedkekpncldlrgv
crtdhlcrsrladfhancrasyqtvtscpadnyqaclgsyagmigfdmtpnyvdssptgi
vvspwcscrgsgnmeeecekflrdftenpclrnaiqafgn

  • Chain 'X':
    Sequence, based on SEQRES records:
    >6q2rX (X:)
sslqgpelhgwrppvdcvranelcaaesncssryrtlrqclagrdrntmlankecqaale
vlqesplydcrckrgmkkelqclqiywsihlgltegeefyeaspyepvtsrlsdifrlas
ifsgtgadpvvsaksnhcldaakacnlndnckklrssyisicnreisptercnrrkchka
lrqffdrvpseytyrmlfcscqdqacaerrrqtilpscsyedkekpncldlrgvcrtdhl
crsrladfhancrasyqtvtscpadnyqaclgsyagmigfdmtpnyvdssptgivvspwc
scrgsgnmeeecekflrdftenpclrnaiqafgngtdvngthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q2rX (X:)
pvdcvranelcaaesncssryrtlrqclankecqaalevlqesplydcrckrgmkkelqc
lqiywsihlgefyeaspyepvnhcldaakacnlndnckklrssyisicnreisptercnr
rkchkalrqffdrvpseytyrmlfcscqdqacaerrrqtilpscsyedkekpncldlrgv
crtdhlcrsrladfhancrasyqtvtscpadnyqaclgsyagmigfdmtpnyvdssptgi
vvspwcscrgsgnmeeecekflrdftenpclrnaiqafgn

  • Chain 'Y':
    Sequence, based on SEQRES records:
    >6q2rY (Y:)
lyfsrdayweklyvdqaagtpllyvhalrdapeevpsfrlgqhlygtyrtrlhennwici
qedtgllylnrsldhssweklsvrnhgfplltvylkvflsptslregecqwpgcarvyfs
ffntsfpacsslkprelcfpetrpsfrirenrppgtfhqfrllpvqflcpnisvayrlle
geglpfrcapdslevstrwaldreqrekyelvavctvhagareevvmvpfpvtvydedds
aptfpagvdtasavvefkrkedtvvatlrvfdadvvpasgelvrrytstllpgdtwaqqt
frvehwpnetsvqangsfvratvhdyrlvlnrnlsisenrtmqlavlvndsdfqgpgagv
lllhfnvsvlpvslhlpstyslsvsrrarrfaqigkvcvencqafsginvqyklhssgan
cstlgvvtsaedtsgilfvndtkalrrpkcaelhymvvatdqqtsrqaqaqllvtvegsy
vaeeagcplscavskrrleceecgglgsptgrcewrqgdgkgitrnfstcspstktcpdg
hcdvvetqdinicpqdclrgsivgghepgeprgikagygtcncfpeeekcfcepediqdp
lcdelcrgthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q2rY (Y:)
lyfsrdayweklyvdqaagtpllyvhalrdapeevpsfrlgqhlygtyrtrlhennwici
qedtgllylnrsldhssweklsvrnhgfplltvylkvflscqwpgcarvyfsffntsfpa
csslkprelcfpetrpsfrirenrppgtfhqfrllpvqflcpnisvayrllglpfrcapd
slevstrwaldreqrekyelvavctvheevvmvpfpvtvydeddsaptfpagvdtasavv
efkrkedtvvatlrvfdadvvpasgelvrrytstllpgdtwaqqtfrvehwpnetsvqan
gsfvratvhdyrlvlnrnlsisenrtmqlavlvndsgvlllhfnvsvlpvslhlpstysl
svsrrarrfaqigkvcvencqafsginvqyklhssgancstlgvvtsaedtsgilfvndt
kalrrpkcaelhymvvatdqqtsrqaqaqllvtvegsyvaeeagcplscavskrrlecee
cgglgsptgrcewrqgdgkgitrnfstcspstktcpdghcdvvetqdinicpqdclrgsi
vgghepgeprgikagygtcncfpeeekcfcep

  • Chain 'Z':
    Sequence, based on SEQRES records:
    >6q2rZ (Z:)
lyfsrdayweklyvdqaagtpllyvhalrdapeevpsfrlgqhlygtyrtrlhennwici
qedtgllylnrsldhssweklsvrnhgfplltvylkvflsptslregecqwpgcarvyfs
ffntsfpacsslkprelcfpetrpsfrirenrppgtfhqfrllpvqflcpnisvayrlle
geglpfrcapdslevstrwaldreqrekyelvavctvhagareevvmvpfpvtvydedds
aptfpagvdtasavvefkrkedtvvatlrvfdadvvpasgelvrrytstllpgdtwaqqt
frvehwpnetsvqangsfvratvhdyrlvlnrnlsisenrtmqlavlvndsdfqgpgagv
lllhfnvsvlpvslhlpstyslsvsrrarrfaqigkvcvencqafsginvqyklhssgan
cstlgvvtsaedtsgilfvndtkalrrpkcaelhymvvatdqqtsrqaqaqllvtvegsy
vaeeagcplscavskrrleceecgglgsptgrcewrqgdgkgitrnfstcspstktcpdg
hcdvvetqdinicpqdclrgsivgghepgeprgikagygtcncfpeeekcfcepediqdp
lcdelcrgthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6q2rZ (Z:)
lyfsrdayweklyvdqaagtpllyvhalrdapeevpsfrlgqhlygtyrtrlhennwici
qedtgllylnrsldhssweklsvrnhgfplltvylkvflscqwpgcarvyfsffntsfpa
csslkprelcfpetrpsfrirenrppgtfhqfrllpvqflcpnisvayrllglpfrcapd
slevstrwaldreqrekyelvavctvheevvmvpfpvtvydeddsaptfpagvdtasavv
efkrkedtvvatlrvfdadvvpasgelvrrytstllpgdtwaqqtfrvehwpnetsvqan
gsfvratvhdyrlvlnrnlsisenrtmqlavlvndsgvlllhfnvsvlpvslhlpstysl
svsrrarrfaqigkvcvencqafsginvqyklhssgancstlgvvtsaedtsgilfvndt
kalrrpkcaelhymvvatdqqtsrqaqaqllvtvegsyvaeeagcplscavskrrlecee
cgglgsptgrcewrqgdgkgitrnfstcspstktcpdghcdvvetqdinicpqdclrgsi
vgghepgeprgikagygtcncfpeeekcfcep